Welcome to hiintermediates.com,intermediates trading platform
Home > products > 2,3-Naphthalenediol,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-

2,3-Naphthalenediol,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro- cas no:42200-33-9

Synonyms: Anabet;Corgard; Nadolol; SQ 11725; Solgol

Identification
Name2,3-Naphthalenediol,5-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,2,3,4-tetrahydro-
CAS42200-33-9
SynonymsAnabet;Corgard; Nadolol; SQ 11725; Solgol
EINECS(EC#)255-706-3
Molecular FormulaC17H27 N O4
Molecular Weight309.45
Chemical Properties
AppearanceWhite Solid
refractive index1.573
storage tempRefrigerator
Safety Data

Safety

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects by ingestion: visual field changes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. Used to reduce cardiac arrhythmias, lower blood pressure and treat angina pectoris.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 767, 1990.
man TDLo oral 571ug/kg (0.571mg/kg) SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE Annals of Internal Medicine. Vol. 97, Pg. 454, 1982.
man TDLo oral 64mg/kg/4W-I (64mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF ENDOCRINE PANCREAS British Journal of Clinical Practice. Vol. 43, Pg. 74, 1989.
mouse LD50 intraperitoneal 270mg/kg (270mg/kg)   "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980Vol. -, Pg. 295, 1980.
mouse LD50 intravenous 47100ug/kg (47.1mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
mouse LD50 oral 3800mg/kg (3800mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: ANTIPSYCHOTIC
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 527, 1981.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 527, 1981.
rat LD50 intraperitoneal 322mg/kg (322mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
rat LD50 intravenous 59200ug/kg (59.2mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 1461, 1985.
rat LD50 oral 5300mg/kg (5300mg/kg)   "Pharmacology of Antihypertensive Drugs," Scriabine, A., ed., New York, Raven Press, 1980Vol. -, Pg. 295, 1980.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 527, 1981.

supplier list

Varda Biotech Pvt. Ltd.
Tel:+91-(22)-6693 5686
Address: #110 & 111 Kartik Complex, New Link Road, Andheri (W), Mumbai, Maharashtra 400 053,
Beijing HuameiHuli Biochem Ltd
Tel:010-86181995
Address: Beijing TongZhou District
Boc Sciences
Tel:1-631-5046093
Address: 45-16 Ramsey Road Shirley, NY 11967, USA
VETCHEM Biochemistry Science
Tel:+86-21-593837
Address: No.2 Jinshanwei Industrial Zon,Shanghai 200120 China
lotuschem
Tel:852-29738324
Address: Rm. 907. JCD116 Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong
ACIC Fine Chemicals Inc.
Tel:+1-(800)-265-6727
Address: 11772 West Sample Road, Coral Springs, Florida 33065,
Changzhou Carbochem Co.,Ltd
Tel:+86-(519)-8659-5536
Address: 3-1308,No. 1288 Zhongwu Avenue, Changzhou, Jiangsu,
Apotex NZ
Tel:+64-9-444-2073
Address: Apotex NZ Ltd , 32 Hillside Road,Glenfield, Auckland,New Zealand
Fine Chem Trading LTD
Tel:+44-079-7062-7591
Address: PO Box 292, Greenford, UB6 9ZL, England
Transo-Pharm
Tel:+49 4107 8779 333
Address: B榛畉bek 5 22962 Siek Germany
Tianjin Harmony Technology Development Co., Ltd.
Tel:
Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China
Hangzhou J&H Chemical Co., Ltd
Tel:86-571-87396430
Address: No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China
ARIZON CHEMICALS
Tel:90-523-1234567
Address: Yavuz Sultan Selim Cad. 118. Sk. No:29
S.S.T. Corporation
Tel:+1-(973)-473-4300
Address: 635 Brighton Road, Clifton, New Jersey 07012,

Home   |   About Us   |   Service   |   Links   |   Add to  Favorite

Copyright©2011 HiIntermediates ICP: B2-20090288 浙ICP备09045134号-49
Tel: +86-0571-89739792