Cyproterone acetate cas no:427-51-0
Synonyms: SH 714;Cyproteron-r acetate;6-Chloro-1beta,2beta-dihydro-17-hydroxy-3H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate;Cyproteroneacetate;Cyproterone acetate (JAN/USAN);Cyproviron;1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate;6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate;3H-Cyclopropa[1,2]pregna-1,4,6-triene-3, 20-dione, 17- (acetyloxy)-6-chloro-1,2-dihydro-, (1.beta., 2.beta.)-;6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate;17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione;1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate;Cyproterone acetate [USAN:JAN];Cyproterone 17-O-acetate;6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione 17-acetate;SH 80714;3H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-, acetate;6-Chloro-17-hydroxy-1.alpha.,2.alpha.-methylenepregna-4, 6-diene-3,20-dione acetate;Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1.alpha.,2.alpha.-methylene-, acetate;Cyproterone 17.alpha.-acetate;1, 2.alpha.-Methylene-6-chloro-(sup 4,6)-pregnadiene-17.alpha.-ol-3, 20-dione 17alpha-acetate;Progesterone, 6-chloro-6-dehydro-17-hydroxy-1.alpha.,2.alpha.-methylene-, acetate;Cyproterone 17alpha-acetate;3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20- dione,17-(acetyloxy)-6-chloro-1,2-dihydro-,(1a,2a)-;Cyproteron acetate;Cyprosterone acetate;Androcur;6-chloro-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate;
NameCyproterone acetate
CAS427-51-0
SynonymsSH 714;Cyproteron-r acetate;6-Chloro-1beta,2beta-dihydro-17-hydroxy-3H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate;Cyproteroneacetate;Cyproterone acetate (JAN/USAN);Cyproviron;1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate;6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate;3H-Cyclopropa[1,2]pregna-1,4,6-triene-3, 20-dione, 17- (acetyloxy)-6-chloro-1,2-dihydro-, (1.beta., 2.beta.)-;6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate;17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione;1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate;Cyproterone acetate [USAN:JAN];Cyproterone 17-O-acetate;6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione 17-acetate;SH 80714;3H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-, acetate;6-Chloro-17-hydroxy-1.alpha.,2.alpha.-methylenepregna-4, 6-diene-3,20-dione acetate;Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1.alpha.,2.alpha.-methylene-, acetate;Cyproterone 17.alpha.-acetate;1, 2.alpha.-Methylene-6-chloro-(sup 4,6)-pregnadiene-17.alpha.-ol-3, 20-dione 17alpha-acetate;Progesterone, 6-chloro-6-dehydro-17-hydroxy-1.alpha.,2.alpha.-methylene-, acetate;Cyproterone 17alpha-acetate;3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20- dione,17-(acetyloxy)-6-chloro-1,2-dihydro-,(1a,2a)-;Cyproteron acetate;Cyprosterone acetate;Androcur;6-chloro-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate;
EINECS(EC#)207-048-3
Molecular FormulaC24H29ClO4
Molecular Weight416.94
AppearanceOdour
refractive index1.582
storage temp2-8°C
Hazard Xn:Harmful
Risk R20/21/22;R40
Safety
Safety Information of Cyproterone acetate (CAS NO.427-51-0):
Hazard Codes:Xn,Xi 
Risk Statements:20/21/22-40-36/37/38
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
40:Limited evidence of a carcinogenic effect
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:22-36-26
22:Do not breathe dust
36:Wear suitable protective clothing
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
WGK Germany:3
RTECS:GZ2230000
Hazardous Substances Data:427-51-0(Hazardous Substances Data)
Questionable carcinogen with experimental tumorigenic and teratogenic data. Moderately toxic by intraperitoneal route. Human reproductive effects by ingestion and possibly other routes: abnormal spermatogenesis, changes in the testes, epididymis, and sperm duct, impotence, and other paternal effects. Experimental reproductive effects. Mutation data reported. Used as a drug to arrest precocious puberty in children and hirsutism in women. A steroid. When heated to decomposition it emits toxic fumes of Cl−.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| man |
LDLo |
oral |
171mg/kg/17W- (171mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Israel Journal of Medical Sciences. Vol. 30, Pg. 238, 1994. |
| man |
TDLo |
oral |
514mg/kg/7W-I (514mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"
LIVER: "HEPATITIS, FIBROUS (CIRRHOSIS, POST-NECROTIC SCARRING)"
LIVER: LIVER FUNCTION TESTS IMPAIRED |
Australian and New Zealand Journal of Medicine. Vol. 26, Pg. 724, 1996. |
| mouse |
LD50 |
intraperitoneal |
3300mg/kg (3300mg/kg) |
|
Drugs in Japan Vol. 6, Pg. APP-4, 1982. |
| mouse |
LD50 |
oral |
> 5gm/kg (5000mg/kg) |
|
Drugs in Japan Vol. 6, Pg. APP-4, 1982. |
| mouse |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
|
Drugs in Japan Vol. 6, Pg. APP-4, 1982. |
| rat |
LD50 |
intraperitoneal |
565mg/kg (565mg/kg) |
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982. |
| rat |
LD50 |
oral |
> 5gm/kg (5000mg/kg) |
|
Drugs in Japan Vol. 6, Pg. APP-4, 1982. |
| rat |
LD50 |
subcutaneous |
> 5gm/kg (5000mg/kg) |
|
Drugs in Japan Vol. 6, Pg. APP-4, 1982. |
