Androst-1-en-3-one,17-(acetyloxy)-1-methyl-, (5a,17b)- cas no:434-05-9

NameAndrost-1-en-3-one,17-(acetyloxy)-1-methyl-, (5a,17b)-
CAS434-05-9
Synonyms5a-Androst-1-en-3-one, 17b-hydroxy-1-methyl-, acetate(6CI,8CI);1-Methyl-17b-hydroxy-5a-androst-1-en-3-oneacetate;1-Methyl-17b-hydroxy-5a-androst-1-en-3-one-17b-acetate;1-Methyl-5a-androst-1-en-17b-ol-3-one acetate;17b-Hydroxy-1-methyl-5a-androst-1-en-3-one acetate;Methenolone 17-acetate;Methenolone acetate;NSC 74226;Nibal;Primobolan;Primobolan Tablets;Primobolone;Primonabol;SH 567;SH567a;SQ 16496
EINECS(EC#)207-097-0
Molecular FormulaC₂₂H₃₂O₃
Molecular Weight344.54

refractive index1.536

Safety Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

CHEMICAL IDENTIFICATION

RTECS NUMBER :

BV8408500

CHEMICAL NAME :

5-alpha-Androst-1-en-3-one, 17-beta-hydroxy-1-methyl-, acetate

CAS REGISTRY NUMBER :

434-05-9

LAST UPDATED :

199309

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C22-H32-O3

MOLECULAR WEIGHT :

344.54

WISWESSER LINE NOTATION :

L E5 B666 OV LUTJ A1 E1 FOV1 K1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,835,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

200 mg/kg

SEX/DURATION :

male 10 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 14,330,1964

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

60 mg/kg

SEX/DURATION :

female 17-20 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - urogenital system

REFERENCE :

AVBIB9 Advances in the Biosciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967- Volume(issue)/page/year: 13,71,1974