Dacarbazine cas no:4342-03-4
Synonyms: Dimethyltriazenoimidazolecarboxamide;Di-me-triazenoimidazolecarboxamide;Biocarbazine R;Dtic-Dome (TN);DTIE;Dacarbazine (JAN/USP);Imidazole-4-carboxamide, 5- (3, 3-dimethyl-1-triazeno)-;4-(5)-(3, 3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide;Carboxamide, 5-(3,3-dimethyl-1-triazeno)imidazole-4-;5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide;1H-Imidazole-4-carboxamide, 5- (3,3-dimethyl-1-triazenyl)-;4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide;5-(Dimethyltriazeno)imidazole-4-carboximide;4-(Dimethyltriazeno)imidazole-5-carboxamide;Carboxamide, 5-(3, 3-dimethyl-1-triazeno)imidazole-4-;Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-;(5Z)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide;ICDT;DIC;4-(or 5)-(3, 3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide;Deticene;1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-;4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide;4-(3, 3-Dimethyl-1-triazeno)imidazole-5-carboxamide;5-(Dimethyltriazeno)imidazole-4-carboxamide;1H-Imidazole-4-carboxamide,5-(3,3- dimethyl-1-triazenyl)-;DTIC;Imidazole-4(or 5)-carboxamide, 5(or 4)-(3, 3-dimethyl-1-triazeno)-;Darcarbazinum;
NameDacarbazine
CAS4342-03-4
SynonymsDimethyltriazenoimidazolecarboxamide;Di-me-triazenoimidazolecarboxamide;Biocarbazine R;Dtic-Dome (TN);DTIE;Dacarbazine (JAN/USP);Imidazole-4-carboxamide, 5- (3, 3-dimethyl-1-triazeno)-;4-(5)-(3, 3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide;Carboxamide, 5-(3,3-dimethyl-1-triazeno)imidazole-4-;5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide;1H-Imidazole-4-carboxamide, 5- (3,3-dimethyl-1-triazenyl)-;4-(5)-(3,3-Dimethyl-1-triazeno)imidazole-5(4)-carboxamide;5-(Dimethyltriazeno)imidazole-4-carboximide;4-(Dimethyltriazeno)imidazole-5-carboxamide;Carboxamide, 5-(3, 3-dimethyl-1-triazeno)imidazole-4-;Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-;(5Z)-5-(dimethylaminohydrazinylidene)imidazole-4-carboxamide;ICDT;DIC;4-(or 5)-(3, 3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide;Deticene;1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-;4-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-5-carboxamide;4-(3, 3-Dimethyl-1-triazeno)imidazole-5-carboxamide;5-(Dimethyltriazeno)imidazole-4-carboxamide;1H-Imidazole-4-carboxamide,5-(3,3- dimethyl-1-triazenyl)-;DTIC;Imidazole-4(or 5)-carboxamide, 5(or 4)-(3, 3-dimethyl-1-triazeno)-;Darcarbazinum;
EINECS(EC#)224-396-1
Molecular FormulaC6H10N6O
Molecular Weight182.18
AppearanceYellowish or reddish powder
refractive index1.678
storage temp2-8°C
Hazard T:Toxic
Risk R45;R46;R20/21/22;R36/37/38
Safety
Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by intraperitoneal and parenteral routes. Moderately toxic by ingestion and intravenous routes. Experimental teratogenic effects. Human systemic effects by intravenous route: nausea or vomiting, leukopenia (reduced white blood cell count), and changes in dehydrogenase enzymatic activity. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:??
T,
Xi,
Xn
Risk Statements: 45-46-20/21/22-36/37/38?
R45:May cause cancer.?
R46:May cause heritable genetic damage.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:? 53-36/37/39-45-37/39-36-26?
S53:Avoid exposure - obtain special instructions before use.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S37/39:Wear suitable gloves and eye/face protection.?
S36:Wear suitable protective clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: NI3950000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| hamster |
LD10 |
parenteral |
250mg/kg (250mg/kg) |
? |
Journal of Surgical Oncology. Vol. 15, Pg. 355, 1980. |
| human |
TDLo |
intravenous |
3500ug/kg (3.5mg/kg) |
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: LEUKOPENIA |
Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 83, 1973. |
| mouse |
LD50 |
intraperitoneal |
567mg/kg (567mg/kg) |
? |
Cancer Treatment Reports. Vol. 62, Pg. 721, 1978. |
| mouse |
LD50 |
intravenous |
466mg/kg (466mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ANTIPSYCHOTIC |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 3105, 1981. |
| mouse |
LD50 |
oral |
2032mg/kg (2032mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ANTIPSYCHOTIC |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 3105, 1981. |
| rat |
LD50 |
intraperitoneal |
350mg/kg (350mg/kg) |
? |
Archiv fuer Geschwulstforschung. Vol. 50, Pg. 306, 1980. |
| rat |
LD50 |
intravenous |
411mg/kg (411mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ANTIPSYCHOTIC |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 3105, 1981. |
| rat |
LD50 |
oral |
2147mg/kg (2147mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ANTIPSYCHOTIC |
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 9, Pg. 3105, 1981. |
