438-41-5|3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, hydrochloride (1:1)Products Supply

3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, hydrochloride (1:1) cas no:438-41-5

Synonyms: 3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, monohydrochloride (9CI);3H-1,4-Benzodiazepine, 7-chloro-2-(methylamino)-5-phenyl-, 4-oxide,monohydrochloride (6CI,8CI);7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide hydrochloride;A-Poxide; Ansiacal; Benzodiapin; Cebrum; Chlordiazepoxide hydrochloride;Chlordiazepoxide monohydrochloride; Chlorodiazepoxide hydrochloride; Contol;Corax; Disarim; Equibral; Labican; Lentotran; Librium; Librium hydrochloride;Methaminodiazepoxide hydrochloride; NSC 115748; OCM; Psichial; Psicoterina; Reliberan;Ro 5-0690; SK-Lygen; Seren Vita; Viansin

Identification

Name3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, hydrochloride (1:1)
CAS438-41-5
Synonyms3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, monohydrochloride (9CI);3H-1,4-Benzodiazepine, 7-chloro-2-(methylamino)-5-phenyl-, 4-oxide,monohydrochloride (6CI,8CI);7-Chloro-2-(methylamino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide hydrochloride;A-Poxide; Ansiacal; Benzodiapin; Cebrum; Chlordiazepoxide hydrochloride;Chlordiazepoxide monohydrochloride; Chlorodiazepoxide hydrochloride; Contol;Corax; Disarim; Equibral; Labican; Lentotran; Librium; Librium hydrochloride;Methaminodiazepoxide hydrochloride; NSC 115748; OCM; Psichial; Psicoterina; Reliberan;Ro 5-0690; SK-Lygen; Seren Vita; Viansin
EINECS(EC#)207-117-8
Molecular FormulaC16H14 Cl N3 O . Cl H
Molecular Weight336.24

Chemical Properties

Appearancewhite crystalline powder

Safety Data

Hazard Xn
Risk R22
Safety

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Human systemic effects: ataxia, distorted perceptions, hallucinations, somnolence, and surface EEG changes. Mutation data reported. A minor tranquilizer. When heated to decomposition it emits very toxic fumes of HCl and NO_x.
Safety Information of Methaminodiazepoxide hydrochloride (CAS NO.438-41-5):
Hazard Codes: Xn
Risk Statements: 22-62-63-68
22: Harmful if swallowed
62: Possible risk of impaired fertility
63: Possible risk of harm to the unborn child
68: Possible risk of irreversible effects
Safety Statements: 22-36/37
22: Do not breathe dust
36: Wear suitable protective clothing
37: Wear suitable gloves

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	1gm/kg (1000mg/kg)		"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 71, 1973.
man	TDLo	oral	39mg/kg/30D-I (39mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: ATAXIA	Clinical Toxicology. Vol. 2, Pg. 5, 1969.
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		Journal of Medicinal Chemistry. Vol. 14, Pg. 1106, 1971.
mouse	LD50	intravenous	95mg/kg (95mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Journal of Pharmacology and Experimental Therapeutics. Vol. 129, Pg. 163, 1960.
mouse	LD50	oral	530mg/kg (530mg/kg)		"Benzodinzenines," Garattini, S., et al., New York, Raven Press, 1973Vol. -, Pg. 39, 1973.
mouse	LD50	parenteral	700mg/kg (700mg/kg)		United States Patent Document. Vol. #4371536,
mouse	LD50	subcutaneous	530mg/kg (530mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 159, 1972.
quail	LD50	oral	1gm/kg (1000mg/kg)		Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
rabbit	LD50	intravenous	36mg/kg (36mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: REGIDITY BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)	International Journal of Neuropharmacology. Vol. 5, Pg. 305, 1966.
rabbit	LD50	oral	590mg/kg (590mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 178, Pg. 216, 1969.
rat	LD50	intraperitoneal	276mg/kg (276mg/kg)		Toxicology and Applied Pharmacology. Vol. 16, Pg. 556, 1970.
rat	LD50	intravenous	165mg/kg (165mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 159, 1972.
rat	LD50	oral	537mg/kg (537mg/kg)		Toxicology and Applied Pharmacology. Vol. 16, Pg. 556, 1970.
rat	LD50	subcutaneous	800mg/kg (800mg/kg)		"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 71, 1973.
women	TDLo	oral	8400ug/kg/2W- (8.4mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA	Clinical Toxicology. Vol. 2, Pg. 5, 1969.

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3H-1,4-Benzodiazepin-2-amine,7-chloro-N-methyl-5-phenyl-, 4-oxide, hydrochloride (1:1) cas no:438-41-5

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