10H-Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2) cas no:440-17-5

Name10H-Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, hydrochloride (1:2)
CAS440-17-5
Synonyms10H-Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride(9CI);Phenothiazine,10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride(6CI,8CI);2-Trifluoromethyl-10-[3-(1-methyl-4-piperazinyl)propyl]phenothiazinedihydrochloride;2-Trifluoromethyl-10-[3'-(1-methyl-4-piperazinyl)propyl]phenothiazinedihydrochloride;Eskazine;Eskazinyl;Fluoperazine;Jatroneural;Modalina;SKF5019;Stelazine;Terfluzine;Trazine;Trifluoperazine dihydrochloride;Trifluoperazine hydrochloride;Trifluoroperazine dihydrochloride;Trifluoroperazine hydrochloride;Triftazin;Triphthasine;Triphthazine;Triphthazine dihydrochloride;Tryptazine;Tryptazine dihydrochloride;
EINECS(EC#)207-123-0
Molecular FormulaC₂₁H₂₆Cl₂F₃N₃S
Molecular Weight480.42

AppearanceCream fine powder
storage temp2-8°C

Hazard Xn:Harmful;
Risk R22
Safety

Hazard Codes:  Xn
Risk Statements:  22
22:  Trifluperazine dihydrochloride (440-17-5) is harmful if swallowed .
Safety Statements:  36
36:  Wear suitable protective clothing 
WGK Germany:  3
RTECS:  SP1750000
F : 3-10

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SP1750000

CHEMICAL NAME :

Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromet hyl)-, dihydrochloride

CAS REGISTRY NUMBER :

440-17-5

LAST UPDATED :

199707

DATA ITEMS CITED :

18

MOLECULAR FORMULA :

C21-H24-F3-N3-S.2Cl-H

MOLECULAR WEIGHT :

480.46

WISWESSER LINE NOTATION :

T C666 BN ISJ EXFFF B3- AT6N DNTJ D1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

1143 ug/kg/1D-I

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Behavioral - muscle contraction or spasticity

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

543 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

424 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

133 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

82 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

>20 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Behavioral - rigidity (including catalepsy)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

65 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

660 ug/m3/4H/17W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - urine volume increased Endocrine - changes in thyroid weight Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

660 ug/m3/4H/17W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - urine volume increased Endocrine - changes in thyroid weight Blood - changes in erythrocyte (RBC) count

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Unreported

DOSE :

220 mg/kg

SEX/DURATION :

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

80 ug/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

80 ug/kg/24H

REFERENCE :

FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 25,615,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3217 No. of Facilities: 82 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1343 (estimated) No. of Female Employees: 617 (estimated)