443-48-1|MetronidazoleProducts Supply - Chemical intermediates Network

Metronidazole cas no:443-48-1

Synonyms: Bexon;Vagilen;1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole;Meronidal;Trikojol;Novonidazol;RP 8823;Eumin;Metronidazole (JP14/USP);Bayer 5360;Trichopol;Trichex;Sanatrichom;Nalox;Trikamon;1-Hydroxyethyl-2-methyl-5-nitroimidazole;Metric 21;Monasin;Giatricol;Orvagil;MTZ;Metronidazol;NIDA;Trichazol;Flagyl;Deflamon;Entizol;2-Methyl-1-(2-hydroxyethyl)-5-nitroimidazole;1-(.beta.-Hydroxyethyl)-2-methyl-5-nitroimidazole;Trikozol;1H-Imidazole-1-ethanol,2-methyl-5-nitro-;1-(.beta.-Ethylol)-2-methyl-5-nitro-3-azapyrrole;Klion;Arilin;Clont;Trimeks;Danizol;Efloran;Methronidazole;Trivazol;Acromona;1-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole;Flagesol;Tricocet;Monagyl;Vertisal;Prestwick_334;Klont;Flegyl;Tricowas B;Trichomonacid pharmachim;Trichopal;Trichocide;Flagemona;Trichomol;Metronidaz;1H-Imidazole-1-ethanol, 2-methyl-5-nitro-;1-(β-Ethylol)-2-methyl-5-nitro-3-azapyrrole;1-(β-Hydroxyethyl)-2-methyl-5-nitroimidazole;NSC-50364;1-(β-Oxyethyl)-2-methyl-5-nitroimidaz-ole;2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol;

Identification

NameMetronidazole
CAS443-48-1
SynonymsBexon;Vagilen;1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole;Meronidal;Trikojol;Novonidazol;RP 8823;Eumin;Metronidazole (JP14/USP);Bayer 5360;Trichopol;Trichex;Sanatrichom;Nalox;Trikamon;1-Hydroxyethyl-2-methyl-5-nitroimidazole;Metric 21;Monasin;Giatricol;Orvagil;MTZ;Metronidazol;NIDA;Trichazol;Flagyl;Deflamon;Entizol;2-Methyl-1-(2-hydroxyethyl)-5-nitroimidazole;1-(.beta.-Hydroxyethyl)-2-methyl-5-nitroimidazole;Trikozol;1H-Imidazole-1-ethanol,2-methyl-5-nitro-;1-(.beta.-Ethylol)-2-methyl-5-nitro-3-azapyrrole;Klion;Arilin;Clont;Trimeks;Danizol;Efloran;Methronidazole;Trivazol;Acromona;1-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole;Flagesol;Tricocet;Monagyl;Vertisal;Prestwick_334;Klont;Flegyl;Tricowas B;Trichomonacid pharmachim;Trichopal;Trichocide;Flagemona;Trichomol;Metronidaz;1H-Imidazole-1-ethanol, 2-methyl-5-nitro-;1-(β-Ethylol)-2-methyl-5-nitro-3-azapyrrole;1-(β-Hydroxyethyl)-2-methyl-5-nitroimidazole;NSC-50364;1-(β-Oxyethyl)-2-methyl-5-nitroimidaz-ole;2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol;
EINECS(EC#)207-136-1
Molecular FormulaC₆H₉N₃O₃
Molecular Weight171.15

Chemical Properties

AppearanceWhite to slightly yellow crystalline powder.
refractive index1.612
storage temp2-8°C

Safety Data

Hazard T:Toxic
Risk R40;R46;R45
Safety

Hazard Codes of Metronidazole (CAS NO.443-48-1): Harmful Xn Toxic T
Risk Statements: 40-46-45
R40: Limited evidence of a carcinogenic effect.
R45: May cause cancer.
R46: May cause heritable genetic damage.
Safety Statements: 36/37-45-53
S36/37: Wear suitable protective clothing and gloves.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53: Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: NI5600000
F: 8
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Human systemic effects by ingestion: paresthesia, nerve or sheath structural changes, eye changes, tremors, fever, jaundice and other liver changes, hearing-acuity changes, somnolence, and ataxia. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

HS Code 29332990

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	39600mg/kg/4W (39600mg/kg)	PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE BEHAVIORAL: HEADACHE	International Journal of Clinical Pharmacology Research. Vol. 19, Pg. 83, 1999.
man	TDLo	oral	3570ug/kg/D (3.57mg/kg)	LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" LIVER: OTHER CHANGES	JAMA, Journal of the American Medical Association. Vol. 193, Pg. 1128, 1965.
man	TDLo	oral	1030mg/kg/8W (1030mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS PERIPHERAL NERVE AND SENSATION: STRUCTURAL CHANGE IN NERVE OR SHEATH	British Medical Journal. Vol. 2, Pg. 610, 1977.
mouse	LD50	intraperitoneal	870mg/kg (870mg/kg)		Polish Journal of Pharmacology and Pharmacy. Vol. 42, Pg. 471, 1990.
mouse	LD50	oral	3800mg/kg (3800mg/kg)	?	Journal of Medicinal Chemistry. Vol. 20, Pg. 1522, 1977.
mouse	LD50	subcutaneous	3640mg/kg (3640mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.
rat	LD50	oral	3gm/kg (3000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Oyo Yakuri. Pharmacometrics. Vol. 8, Pg. 1089, 1974.
women	TDLo	intravenous	100mg/kg/5D-I (100mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: IRRITABILITY BEHAVIORAL: TOXIC PSYCHOSIS	American Journal of Psychiatry. Vol. 154, Pg. 1169, 1997.
women	TDLo	oral	12mg/kg (12mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR	British Medical Journal. Vol. 292, Pg. 174, 1986.
women	TDLo	oral	40mg/kg (40mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Southern Medical Journal. Vol. 78, Pg. 627, 1985.

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Metronidazole cas no:443-48-1

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