Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)- cas no:4449-51-8
Synonyms: Veratraman-3-ol, 17,23-epoxy-, (3b,23b)-;(-)-Cyclopamine;11-Deoxojervine;11-Deoxyjervine;Cyclopamine(8CI);Jervine, 11-deoxo- (7CI);
NameSpiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol,1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-,(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-
CAS4449-51-8
SynonymsVeratraman-3-ol, 17,23-epoxy-, (3b,23b)-;(-)-Cyclopamine;11-Deoxojervine;11-Deoxyjervine;Cyclopamine(8CI);Jervine, 11-deoxo- (7CI);
Molecular FormulaC27H41NO2
Molecular Weight411.69
AppearanceWhite crystalline solid
refractive index1.583
storage temp2-8°C
Hazard Xi: Irritant;
Safety
A poison by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Cyclopamine (CAS NO.4449-51-8):
Hazard Codes: Xi 
Safety Statements: 22-24/25
22: Do not breathe dust
24: Avoid contact with skin
25: Avoid contact with eyes
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| hamster |
LDLo |
oral |
170mg/kg (170mg/kg) |
|
Proceedings of the Society for Experimental Biology and Medicine. Vol. 149, Pg. 302, 1975. |
| mouse |
LDLo |
oral |
180mg/kg (180mg/kg) |
|
Proceedings of the Society for Experimental Biology and Medicine. Vol. 149, Pg. 302, 1975. |
