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Azathioprine cas no:446-86-6

Synonyms: 1H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- (9CI);Purine,6-[(1-methyl-4-nitroimidazol-5-yl)thio]- (6CI,8CI);6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-(1-Methyl-4-nitromidazol-5-ylthio)purine;Azamune;Azanin;Azathioprin;Azoran;BW 57-322;Imuran;Imurek;Imurel;Muran;NSC 39084;

Identification
NameAzathioprine
CAS446-86-6
Synonyms1H-Purine,6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- (9CI);Purine,6-[(1-methyl-4-nitroimidazol-5-yl)thio]- (6CI,8CI);6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine;6-(1-Methyl-4-nitromidazol-5-ylthio)purine;Azamune;Azanin;Azathioprin;Azoran;BW 57-322;Imuran;Imurek;Imurel;Muran;NSC 39084;
EINECS(EC#)207-175-4
Molecular FormulaC9H7N7O2S
Molecular Weight277.26
Chemical Properties
AppearanceLight-yellow crystalline powder
refractive index1.923
storage tempFreezer
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
HazardclassIRRITANT
Safety Data

Hazard Xi,T,Xn
Risk R45
Safety

Confirmed human carcinogen producing bladder tumors and leukemia. Poison by subcutaneous, intradermal, and intraperitoneal routes. Moderately toxic by ingestion. Human systemic effects: liver changes, hypermotility, diarrhea, nausea or vomiting, increased body temperature, BP lowering, decreased urine volume or anuria, normocytic anemia, bone marrow changes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. An immunosuppressant.

Hazard Codes:? XiIrritant,TToxic,XnHarmful
Risk Statements:? 45-22-36/37/38-20/21/22?
R45:May cause cancer.?
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:? 53-22-26-36/37-45-36?
S53:Avoid exposure - obtain special instructions before use.?
S22:Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36:Wear suitable protective clothing.
Hazard Note:? Irritant


Toxicity
1. ???

mma-sat 300 μmol/L

??? EXPEAM ?? Experientia. 40 (1984),370.
2. ???

cyt-hmn-unr 1074?mg/kg/4Y

??? MUREAV ?? Mutation Research. 94 (1982),501.
3. ???

orl-wmn TDLo:273?mg/kg/13?W-C:CAR,BLD

??? BMJOAE ?? British Medical Journal. 4 (1972),235.
4. ???

orl-wmn TD:3?g/kg/3.5Y-C:CAR,KID

??? JAMAAP ?? JAMA, Journal of the American Medical Association. 237 (1977),152.
5. ???

orl-wmn TD:5460?mg/kg/6Y-I:CAR,BLD

??? AMSVAZ ?? Acta Medica Scandinavica. 207 (1980),315.
6. ???

orl-man TD:728?mg/kg/43?W-C:CAR,BLD

??? AJMSA9 ?? American Journal of the Medical Sciences. 273 (1977),335.
7. ???

orl-man TD:1565?mg/kg/4Y-C:CAR,BLD

??? AJMEAZ ?? American Journal of Medicine. 57 (1974),885.
8. ???

orl-man TD:3266?mg/kg/3Y-C:CAR,BLD

??? AJMEAZ ?? American Journal of Medicine. 57 (1974),885.
9. ???

orl-wmn TD:2?g/kg/3Y-C:CAR,BLD

??? PGMJAO ?? Postgraduate Medical Journal. 53 (1977),173.
10. ???

orl-man LDLo:395?mg/kg/56?W-I:SYS

??? GASTAB ?? Gastroenterology. 90 (1986),446.
11. ?

RTECS:? UO8925000

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