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CHOLINE, with THEOPHYLLINE (1:1) cas no:4499-40-5

Synonyms: OXTRIPHYLLINE;(2-hydroxyethyl)trimethylammoniumcompoundwiththeophylline;choledyl;choledylsa400;cholegyl;choline,compd.withtheophylline(1:1);cholinetheophyllinesalt;cholinophylline

Identification
NameCHOLINE, with THEOPHYLLINE (1:1)
CAS4499-40-5
SynonymsOXTRIPHYLLINE;(2-hydroxyethyl)trimethylammoniumcompoundwiththeophylline;choledyl;choledylsa400;cholegyl;choline,compd.withtheophylline(1:1);cholinetheophyllinesalt;cholinophylline
EINECS(EC#)224-798-7
Molecular FormulaC7H7N4O2•C5H14NO
Molecular Weight283.38
Safety Data

Safety

Poison by ingestion, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: changes in potassium, changes in urine composition, hyperglycemia, metabolic acidosis, nausea or vomiting, tremors, and excitement. When heated to decomposition it emits toxic fumes of NOx and NH3. See also THEOPHYLLINE and CHOLINE.


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intramuscular 185mg/kg (185mg/kg)   Compilation of LD50 Values of New Drugs.
guinea pig LD50 intravenous 118mg/kg (118mg/kg)   Compilation of LD50 Values of New Drugs.
guinea pig LD50 oral 210mg/kg (210mg/kg)   Compilation of LD50 Values of New Drugs.
infant TDLo oral 113mg/kg/31D (113mg/kg)

endocrine: hyperglycemia kidney, ureter, and bladder: other changes in urine composition

Archives of Disease in Childhood. Vol. 53, Pg. 757, 1978.
man TDLo oral 429mg/kg (429mg/kg)

endocrine: hyperglycemia

American Journal of Emergency Medicine. Vol. 3, Pg. 408, 1985.
mouse LD50 intramuscular 360mg/kg (360mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 intravenous 112mg/kg (112mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 oral 770mg/kg (770mg/kg)   Compilation of LD50 Values of New Drugs.
rat LD50 intramuscular 240mg/kg (240mg/kg)   Drugs in Japan Vol. 6, Pg. 278, 1982.
rat LD50 intraperitoneal 185mg/kg (185mg/kg)   Drugs in Japan Vol. 6, Pg. 278, 1982.
rat LD50 oral 600mg/kg (600mg/kg)   Drugs in Japan Vol. 6, Pg. 278, 1982.
women TDLo oral 420mg/kg (420mg/kg)

behavioral: tremor behavioral: excitement gastrointestinal: nausea or vomiting

Southern Medical Journal. Vol. 71, Pg. 965, 1978.

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Wuhan Fortuna Chemical Co., Ltd.
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Jinan Haohua Industry Co., Ltd.
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Address: No.59 Gongye South RD
HangZhou Peak Chemical Co.,Ltd
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Bajaj Healthcare Ltd
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Address: 202-204,Faiz-E-Qutbi, 375,Narshi Natha Street, Mumbai ~ 400 009, India.
Bulk Pharmaceuticals Inc.
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Address: 445 Milner Ave., Unit #1 Scarborough, ON Canada
Apex Drug House
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Address: 28, Mahendra Mansion, Babu Genu Road,Mumbai-400 002.
Tianjin Harmony Technology Development Co., Ltd.
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Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China
Wuhan Senwayer Century chemical Co.,Ltd
Tel:86-27-59009407
Address: 20#Xudong Street,Wuhan China
Hangzhou Dayangchem Co., Ltd.
Tel:86-571-88938639
Address: 9/F Unit 2 ChangdiTorch Building, 259 #WenSan Road
Wuhan Dahua Weiye Pharmaceutical Co.,Ltd
Tel:86-27-59335372
Address: daijiashan 45,jiangan economic departmen zone,wuhan,hubei,China

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