Sulfoxylic acid,mono[[[5-[(3-amino-4-hydroxyphenyl)diarsenyl]-2-hydroxyphenyl]amino]methyl]ester, sodium salt (1:1) cas no:457-60-3

NameSulfoxylic acid,mono[[[5-[(3-amino-4-hydroxyphenyl)diarsenyl]-2-hydroxyphenyl]amino]methyl]ester, sodium salt (1:1)
CAS457-60-3
SynonymsMethanol,[5-[(3-amino-4-hydroxyphenyl)arseno]-2-hydroxyanilino]-, 1-(hydrogensulfoxylate) (ester), monosodium salt (8CI); Sulfoxylic acid,mono[[[5-[(3-amino-4-hydroxyphenyl)diarsenyl]-2-hydroxyphenyl]amino]methyl]ester, monosodium salt (9CI); Neo-I.C.I.; Neoarsphenamine; Neosalvarsan;Novarsenobenzol; Novarsenobillon; Novarsenol; Sodium3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-formaldehydesulfoxylate; Sodium3,3'-diamino-4,4'-dihydroxyarsenobenzene-N-methylene-sulfoxylate; Sodiump,p'-dihydroxy-m,m'-diaminoarsenobenzene-N-monomethanol sulfoxylate
EINECS(EC#)207-273-7
Molecular FormulaC13H14 As2 N2 O4 S . Na
Molecular Weight466.17

Hazard Xn
Risk 22
Safety

Hazard Codes: Xn
Risk Statements: 22
R22: Neosalvarsan (CAS NO.457-60-3) is harmful if swallowed.
Safety Statements: 24/25-36
S24/25: Avoid contact with skin and eyes. 
S36: Wear suitable protective clothing.

Poison by intravenous and subcutaneous routes. When heated to decomposition it emits very toxic fumes of As, NO_x, Na₂O, and SO_x. See also ARSENIC COMPOUNDS.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LDLo	intraperitoneal	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
guinea pig	LDLo	subcutaneous	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
mouse	LD50	intravenous	370mg/kg (370mg/kg)		Therapie. Vol. 2, Pg. 28, 1947.
mouse	LDLo	intraperitoneal	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
mouse	LDLo	subcutaneous	100mg/kg (100mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rabbit	LDLo	intravenous	150mg/kg (150mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rat	LD50	intravenous	318mg/kg (318mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 73, Pg. 12, 1941.
rat	LDLo	intraperitoneal	50mg/kg (50mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.
rat	LDLo	subcutaneous	75mg/kg (75mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 9, Pg. 354, 1917.