458-88-8|Piperidine, 2-propyl-,(2S)-Products Supply

Piperidine, 2-propyl-,(2S)- cas no:458-88-8

Synonyms: Coniine(6CI,8CI);Piperidine,2-propyl-,(S)-;(+)-Coniine;(S)-(+)-Coniine;(S)-2-Propylpiperidine;(S)-Coniine;Cicutin;Cicutine;Conicine;Coniin;Koniin;Coniine,D/L-(RG);(s)-beta-propylpiperidine;d-conicine

Identification

NamePiperidine, 2-propyl-,(2S)-
CAS458-88-8
SynonymsConiine(6CI,8CI);Piperidine,2-propyl-,(S)-;(+)-Coniine;(S)-(+)-Coniine;(S)-2-Propylpiperidine;(S)-Coniine;Cicutin;Cicutine;Conicine;Coniin;Koniin;Coniine,D/L-(RG);(s)-beta-propylpiperidine;d-conicine
EINECS(EC#)207-282-6
Molecular FormulaC8H17 N
Molecular Weight127.26

Chemical Properties

refractive index1.429

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass3.2

Safety Data

Safety

Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic effects. When heated to decomposition Cicutine (CAS NO.458-88-8) emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intravenous	3mg/kg (3mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 35, Pg. 316, 1936.
dog	LDLo	intravenous	25mg/kg (25mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 588, 1948.
frog	LDLo	unreported	375mg/kg (375mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 595, 1948.
guinea pig	LDLo	subcutaneous	50mg/kg (50mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 593, 1948.
mouse	LD50	intravenous	19mg/kg (19mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963.
mouse	LD50	oral	100mg/kg (100mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963.
mouse	LD50	subcutaneous	80mg/kg (80mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Pharmacy and Pharmacology. Vol. 15, Pg. 1, 1963.
rabbit	LDLo	intravenous	15mg/kg (15mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 588, 1948.
rabbit	LDLo	subcutaneous	80mg/kg (80mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Medical Sciences, Part 4: Pharmacology. Vol. 7, Pg. 128, 1933.

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Piperidine, 2-propyl-,(2S)- cas no:458-88-8

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