Bufa-20,22-dienolide,14,15-epoxy-3-hydroxy-, (3b,5b,15b)- cas no:465-39-4
Synonyms: 5b-Bufa-20,22-dienolide, 14,15b-epoxy-3b-hydroxy- (6CI,7CI,8CI);14,15b-Epoxy-3b-hydroxy-5b-bufa-20,22-dienolide;3b-Hydroxy-14,15b-epoxy-5b-bufa-20,22-dienolide;Bufogenin;NSC 90783;Recibufogenin;Resi;Resibufogenin;Respigon;
NameBufa-20,22-dienolide,14,15-epoxy-3-hydroxy-, (3b,5b,15b)-
CAS465-39-4
Synonyms5b-Bufa-20,22-dienolide, 14,15b-epoxy-3b-hydroxy- (6CI,7CI,8CI);14,15b-Epoxy-3b-hydroxy-5b-bufa-20,22-dienolide;3b-Hydroxy-14,15b-epoxy-5b-bufa-20,22-dienolide;Bufogenin;NSC 90783;Recibufogenin;Resi;Resibufogenin;Respigon;
Molecular FormulaC24H32O4
Molecular Weight384.50848
AppearanceWhite to off-white solid.
refractive index1.602
storage tempStore in original container in a cool dark place.
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Safety
Deadly poison by intravenous route. When heated to decomposition it emits acrid smoke and fumes. See also BUFOGENIN B.
RIDADR: 3172
HazardClass: 6.1(a)
PackingGroup: II
Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
frog |
LD50 |
parenteral |
7830ug/kg (7.83mg/kg) |
? |
Drugs of the Future. Vol. 12, Pg. 837, 1987. |
mouse |
LD50 |
intraperitoneal |
14mg/kg (14mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 1239, 1982. |
mouse |
LD50 |
intravenous |
4250ug/kg (4.25mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 899, 1982. |
mouse |
LD50 |
oral |
59800mg/kg (59800mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 1239, 1982. |
mouse |
LD50 |
subcutaneous |
104mg/kg (104mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 1239, 1982. |
rat |
LD50 |
intravenous |
2200ug/kg (2.2mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 899, 1982. |
rat |
LD50 |
parenteral |
21mg/kg (21mg/kg) |
? |
Drugs of the Future. Vol. 12, Pg. 837, 1987. |