Bufa-4,20,22-trienolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-14-hydroxy-,(3b)- cas no:466-06-8

NameBufa-4,20,22-trienolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-14-hydroxy-,(3b)-
CAS466-06-8
SynonymsProscillaridinA (6CI,7CI,8CI); 14-Hydroxy-3b-(rhamnosyloxy)bufa-4,20,22-trienolide; 3b-Rhamnosido-14b-hydroxy-D4,20,22-bufatrienolide; 3b-[(6-Deoxy-a-L-mannopyranosyl)oxy]-14-hydroxybufa-4,20,22-trienolide;A 32686; Caradrin; Cardion; Cardiovite; Carmazon; Coratol;Desglucotransvaaline; Desglucotrnasvaaline; Herzo Proscillan; NSC 7521;PSC-801; Procardin; Procilan; Proscillan; Proscillaridin; Prostosin; Proszine;Protasin; Purosin-TC; Sandoscill; Scillacrist; Scillarenin 3b-rhamnoside; Simeon; Solestril;Stellarid; Talucard; Talusin; Tradenal; Transvaalin, degluco-; Urgilan;Wirnesin
EINECS(EC#)207-370-4
Molecular FormulaC30H42 O8
Molecular Weight530.72

refractive index1.619
storage temp2-8°C

Hazard T: Toxic;
Risk R25
Safety

Poison by ingestion, intravenous, and intraduodenal routes. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes T
Risk Statements 25
R25 : Proscillaridin (CAS NO.466-06-8) is toxic if swallowed.
Safety Statements 28-45 
S28:After contact with skin, wash immediately with plenty of soap-suds. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS UK6650000 
 

1.		orl-rat LD50:56 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 20 (1971),599.
2.		ivn-rat LD50:9 mg/kg		TXAPA9    Toxicology and Applied Pharmacology. 20 (1971),599.
3.		orl-mus LD50:30,500 µg/kg		NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),723.
4.		ivn-mus LD50:23,200 µg/kg		NIIRDN    “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),723.
5.		ivn-cat LD50:111 µg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 20 (1970),1.
6.		idu-cat LDLo:268 µg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 14 (1964),716.
7.		orl-gpg LD50:6810 µg/kg		USXXAM    United States Patent Document. (Commissioner of Patents and Trademarks, Washington, DC 20231) #4230702 .
8.		ivn-gpg LD50:280 µg/kg		ARZNAD    Arzneimittel-Forschung. Drug Research. 20 (1970),1.