DEXAMETHASONE SODIUM SULFATE cas no:466-11-5

NameDEXAMETHASONE SODIUM SULFATE
CAS466-11-5
SynonymsDexamethasone sodium hemisulfate;Dexa-Scheroson (injectable);Dexamethason 21-hemisulfate sodium salt;Dexamethasone sodium sulfate;Dexamethasone 21-(sodium sulphate);Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(sulfooxy)-, monosodium salt, (11beta,16alpha)-;Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-(hydrogen sulfate), monosodium salt;sodium (11beta,16alpha)-9-fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl sulfate
EINECS(EC#)207-374-6
Molecular FormulaC22H29FO8S . Na
Molecular Weight494.5061

Safety

Moderately toxic by intraperitoneal and subcutaneous routes. A steroid. When heated to decomposition it emits toxic fumes of F⁻, SO_x, and Na₂O.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1660mg/kg (1660mg/kg)		Drugs in Japan Vol. 6, Pg. 477, 1982.
mouse	LD50	oral	> 7500mg/kg (7500mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES LIVER: OTHER CHANGES	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 6, 1974.
mouse	LD50	subcutaneous	2020mg/kg (2020mg/kg)		Drugs in Japan Vol. 6, Pg. 477, 1982.
rat	LD50	intramuscular	> 400mg/kg (400mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rat	LD50	intraperitoneal	2180mg/kg (2180mg/kg)		Drugs in Japan Vol. 6, Pg. 477, 1982.
rat	LD50	intravenous	1gm/kg (1000mg/kg)		Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
rat	LD50	oral	> 7500mg/kg (7500mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES LIVER: OTHER CHANGES	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 6, 1974.
rat	LD50	subcutaneous	3450mg/kg (3450mg/kg)		Drugs in Japan Vol. 6, Pg. 477, 1982.