4759-48-2|13-cis-Vitamin A acidProducts Supply - Chemical intermediates Network

13-cis-Vitamin A acid cas no:4759-48-2

Synonyms: Isotretinoin [USAN:BAN:INN];(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoate;Retinoic acid, (13cis)-;13-cis-Retinoic acid;Isotretinoin Retinoic acid;Prestwick_642;Neovitamin A acid;Claravis;Teriosal;Roaccutan;Isotretion;Isotretinoin?;Isotretinoine [INN-French];isoretinoin;4-09-00-02388 (Beilstein Handbook Reference);

Identification

Name13-cis-Vitamin A acid
CAS4759-48-2
SynonymsIsotretinoin [USAN:BAN:INN];(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoate;Retinoic acid, (13cis)-;13-cis-Retinoic acid;Isotretinoin Retinoic acid;Prestwick_642;Neovitamin A acid;Claravis;Teriosal;Roaccutan;Isotretion;Isotretinoin?;Isotretinoine [INN-French];isoretinoin;4-09-00-02388 (Beilstein Handbook Reference);
EINECS(EC#)225-296-0
Molecular FormulaC₂₀H₂₈O₂
Molecular Weight300.44

Chemical Properties

Appearanceyellowish crystalline powder
storage temp?20°C

Safety Data

Hazard T:Toxic
Risk R36/37/38;R61
Safety

Hazard Codes:? Toxic T
Risk Codes:?61-36/37/38-20/21/22
R61:May cause harm to the unborn child.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety?Codes:?53-26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical
advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the
label whenever possible.)
S53: Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: VH6440000
Poison by intraperitoneal route. Moderately toxic by ingestion. A human teratogen by ingestion with fetal developmental abnormalities of the skin and appendages and other postnatal effects. Human reproductive effects. Human systemic effects: decreased immune response, diarrhea, hypermotility, irritative dermatitis, sweating. Human mutation data reported. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	30mg/kg/21W (30mg/kg)	MUSCULOSKELETAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): NAILS: OTHER	American Journal of Diseases of Children. Vol. 142, Pg. 316, 1988.
child	TDLo	oral	360mg/kg/26W- (360mg/kg)	SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	CUTIS; Cutaneous Medicine for the Practitioner. Vol. 38, Pg. 275, 1986.
man	TDLo	oral	24mg/kg/4W-I (24mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES	Gastroenterology. Vol. 93, Pg. 606, 1987.
man	TDLo	oral	37mg/kg/5W-I (37mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE" IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE	Archives of Dermatology. Vol. 122, Pg. 815, 1986.
man	TDLo	unreported	21mg/kg/3W-I (21mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	British Medical Journal. Vol. 290, Pg. 820, 1985.
mouse	LD50	intraperitoneal	138mg/kg (138mg/kg)	?	"The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984Vol. 2, Pg. 287, 1984.
mouse	LD50	oral	3389mg/kg (3389mg/kg)	?	"The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984Vol. 2, Pg. 287, 1984.
rabbit	LD50	oral	1960mg/kg (1960mg/kg)	?	"The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984Vol. 2, Pg. 287, 1984.
rat	LD50	intraperitoneal	901mg/kg (901mg/kg)	?	Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982.
rat	LD50	oral	> 4gm/kg (4000mg/kg)	?	Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982.
women	TDLo	oral	56mg/kg/8W-I (56mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	CUTIS; Cutaneous Medicine for the Practitioner. Vol. 37, Pg. 115, 1986.

supplier list

Nexchem Pharmaceutical Co.,Ltd.: Tel:0086-579-82207640 83182935 83188860; Address: No.1318 Jinsha road, Linjiang industrial zone, Wucheng area, Jinhua city，Zhejiang Province, China. and Dongxi industrial zone

Hwasun Biotechnology Co., Ltd.: Tel:; Address: Rm.505, Bldg. 2,No. 245 Jiachuan RD. Xuhui Dist.,200237, Shanghai, China

Melone Pharmaceutical Co., Ltd.: Tel:; Address: Room 2209锛孨o.232, Jinma Road, Development Zone, Dalian, China

Hangzhou Verychem Science And Technology Co. Ltd.: Tel:; Address: 1108A, 316 Jiaogong Road, Hangzhou, Zhejiang, China

Taizhou Overseas Int'l Ltd.: Tel:+86-576-8881 2802; Address: 126-8 QINGNIAN ROAD JIAOJIANG TAIZHOU ZHEJIANG CHINA

Qilong Chemical Co., Ltd.: Tel:86-574-63858500; Address: No.586, Jiangnan Road,High-tech Park, Ningbo, Zhejiang 315040,

Shanghai Zhongye Pharmaceutial & Chemical Co., Ltd.: Tel:+86-(21)-62038888, 62036888; Address: 13/G, ZhongXing Trade Building, 2020 ZhongShan Road (North), Shanghai 200063,

S.S.T. Corporation: Tel:+1-(973)-473-4300; Address: 635 Brighton Road, Clifton, New Jersey 07012,

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Taizhou Creating Chemical Co. ,Ltd.: Tel:+86-(576)-88827176,88820069; Address: B Suite 12F,JiangbinBuilding,Jiaojiang, Taizhou, Zhejiang,

Shanghai Chely Co. Ltd.: Tel:021- 68885110; Address: #603，Block7，Rongcheng Garden，#9 Rongcheng, Pudong, Shanghai 200120,

Sinobond Imp. & Exp. (Ningbo) Co., Ltd.: Tel:+86-(574)-27669091; Address: Suite 1406 Dongcheng Interational Building 796 Yaoai Road, Ningbo, Zhejiang,

Taizhou New Nitto Biotechnology Co., Ltd.: Tel:+86-(576)-8851-7133; Address: Zhejiang Chemical Industry Zone, Taizhou 318000,

Hande Pharma Limited: Tel:+86-(755)-26031808; Address: No.2-405A & 405B, Bio-incubator Bldg., Gaoxinzhong 1st Rd., Shenzhen Hi-tech Industrial Park, Shenzhen, Guangdong 518057,

Ronas Chemicals Ind. Co., Ltd.: Tel:+86-(28)-86082869; Address: Rome International Plaza,Room 09A,19th Floor,NO.210,West Yulong Street, Chengdu, Qingyang District, Sichuan 610072,

13-cis-Vitamin A acid cas no:4759-48-2

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