4759-48-2|13-cis-Vitamin A acidProducts Supply - Chemical intermediates Network

13-cis-Vitamin A acid cas no:4759-48-2

Synonyms: Isotretinoin [USAN:BAN:INN];(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoate;Retinoic acid, (13cis)-;13-cis-Retinoic acid;Isotretinoin Retinoic acid;Prestwick_642;Neovitamin A acid;Claravis;Teriosal;Roaccutan;Isotretion;Isotretinoin?;Isotretinoine [INN-French];isoretinoin;4-09-00-02388 (Beilstein Handbook Reference);

Identification

Name13-cis-Vitamin A acid
CAS4759-48-2
SynonymsIsotretinoin [USAN:BAN:INN];(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoate;Retinoic acid, (13cis)-;13-cis-Retinoic acid;Isotretinoin Retinoic acid;Prestwick_642;Neovitamin A acid;Claravis;Teriosal;Roaccutan;Isotretion;Isotretinoin?;Isotretinoine [INN-French];isoretinoin;4-09-00-02388 (Beilstein Handbook Reference);
EINECS(EC#)225-296-0
Molecular FormulaC₂₀H₂₈O₂
Molecular Weight300.44

Chemical Properties

Appearanceyellowish crystalline powder
storage temp?20°C

Safety Data

Hazard T:Toxic
Risk R36/37/38;R61
Safety

Hazard Codes:? Toxic T
Risk Codes:?61-36/37/38-20/21/22
R61:May cause harm to the unborn child.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety?Codes:?53-26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical
advice.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the
label whenever possible.)
S53: Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: VH6440000
Poison by intraperitoneal route. Moderately toxic by ingestion. A human teratogen by ingestion with fetal developmental abnormalities of the skin and appendages and other postnatal effects. Human reproductive effects. Human systemic effects: decreased immune response, diarrhea, hypermotility, irritative dermatitis, sweating. Human mutation data reported. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	30mg/kg/21W (30mg/kg)	MUSCULOSKELETAL: OTHER CHANGES SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): NAILS: OTHER	American Journal of Diseases of Children. Vol. 142, Pg. 316, 1988.
child	TDLo	oral	360mg/kg/26W- (360mg/kg)	SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	CUTIS; Cutaneous Medicine for the Practitioner. Vol. 38, Pg. 275, 1986.
man	TDLo	oral	24mg/kg/4W-I (24mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: OTHER CHANGES	Gastroenterology. Vol. 93, Pg. 606, 1987.
man	TDLo	oral	37mg/kg/5W-I (37mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE" IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE	Archives of Dermatology. Vol. 122, Pg. 815, 1986.
man	TDLo	unreported	21mg/kg/3W-I (21mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	British Medical Journal. Vol. 290, Pg. 820, 1985.
mouse	LD50	intraperitoneal	138mg/kg (138mg/kg)	?	"The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984Vol. 2, Pg. 287, 1984.
mouse	LD50	oral	3389mg/kg (3389mg/kg)	?	"The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984Vol. 2, Pg. 287, 1984.
rabbit	LD50	oral	1960mg/kg (1960mg/kg)	?	"The Retinoids, Vol.2," Sporn, M.B., et al., eds., New York, Academic Press, Inc., 1984Vol. 2, Pg. 287, 1984.
rat	LD50	intraperitoneal	901mg/kg (901mg/kg)	?	Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982.
rat	LD50	oral	> 4gm/kg (4000mg/kg)	?	Journal of the American Academy of Dermatology. Vol. 6, Pg. 652, 1982.
women	TDLo	oral	56mg/kg/8W-I (56mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"	CUTIS; Cutaneous Medicine for the Practitioner. Vol. 37, Pg. 115, 1986.

supplier list

Shandong Novatech Pharmaceutical Co., Ltd.: Tel:+86-531-55582725; Address: R801,Lianggu Building, No.6 Qilihe Road,

Saniver Limited: Tel:; Address: 805 Harbour Centre, Tower 2, 8 Hok Cheung St., Hunghom, Kowloon, Hong Kong.

Daebong Incheon factory: Tel:+82-32-817-8800; Address: 692-8, Kojan-dong, Namdong-ku, Incheon, KOREA

Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

INFA S.P.A.: Tel:+39-02-777281; Address: Via Salvini 10, 20122 Milan (Italy)

Hangzhou Starshine Pharmaceutical Co., LTD: Tel:86-571-8696517; Address: Fengqi East Road, Hangzhou, China.

EASYBUYER LTD.,: Tel:+86-21-35015877 +86-13701868511; Address: Room 407, Building 10, Hi-Shanghai Center, No.990 Dalian Rd,Shanghai 200092 China

Nexchem Pharmaceutical Co.,Ltd.: Tel:0086-579-82207640 83182935 83188860; Address: No.1318 Jinsha road, Linjiang industrial zone, Wucheng area, Jinhua city，Zhejiang Province, China. and Dongxi industrial zone

IFFECT CHEMPHAR CO., LTD.: Tel:86-25-84679300; Address: 509, FuXin International Building, No.359 HongWu R

Changzhou ComWin Fine Chemicals Co.,Ltd.: Tel:; Address: 24th Floor, Jiaye International Commercial Plaza, 99 Yanling West Road, Changzhou, Jiangsu, China

Qidong Hudong Chemical Co., Ltd. (Zhangjiagang Fr...: Tel:; Address: Room 2301B Chemical Products Exchange Markets ZhangJiaGang Free Trade Zone Jiangsu P.R.china

Hwasun Biotechnology Co., Ltd.: Tel:; Address: Rm.505, Bldg. 2,No. 245 Jiachuan RD. Xuhui Dist.,200237, Shanghai, China

ZHEJIANG HOLYPHARM BIOTECH CO.,LTD: Tel:86-533-8585678; Address: Room C 13th Floor, West Wing International Garden, No.160 Tianmushan Road, Xihu District, Hangzhou City, China

Zhejiang Medicines & Health Products Import & Exp...: Tel:; Address: ZMC Building,101-2 N. Zhongshan Road,Hangzhou,China.

Ancheng Pharma Limited: Tel:+86-755-82713308; Address: Flat 1812, 18/F., Min Hua Building, 7 Jing Tian Bei Steet, Futian District,Shenzhen,China

13-cis-Vitamin A acid cas no:4759-48-2

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