Colchiceine cas no:477-27-0

NameColchiceine
CAS477-27-0
Synonyms7-Acetamido-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo(a)heptalen-;Benzo(a)heptalen-10(5H)-one, 7-acetamido-6,7-dihydro-9-hydroxy-1,2,3-trimethoxy-;Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-10-hydroxy-1,2,3-trimethoxy-;N-Acetyl trimethylcolchicinic acid;O10-Demethylcolchicine;Acetamide, N-(5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- (9CI);O-Demethylcolchicine
EINECS(EC#)207-512-5
Molecular FormulaC21H23 N O6
Molecular Weight385.45

refractive index1.61
storage tempRefrigerator

Safety

A deadly human poison by ingestion. An experimental poison by intravenous, intraperitoneal and possibly other routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. See also COLCHICINE.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	LDLo	oral	43ug/kg (0.043mg/kg)		Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 250, 1966.
man	LDLo	oral	714mg/kg (714mg/kg)	LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE	Medical Journal of Australia. Vol. 158, Pg. 28, 1993.
mouse	LD50	intraperitoneal	84mg/kg (84mg/kg)	BLOOD: HEMORRHAGE	Cancer Vol. 3, Pg. 124, 1950.
mouse	LD50	intravenous	1mg/kg (1mg/kg)		Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 241, Pg. 1889, 1955.
rat	LD50	intravenous	2500ug/kg (2.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Pharmacology and Toxicology. English translation of FATOAO. Vol. 20, Pg. 284, 1957.
rat	LDLo	subcutaneous	75mg/kg (75mg/kg)		Helvetica Chimica Acta. Vol. 33, Pg. 1606, 1950.
rat	LDLo	unreported	30mg/kg (30mg/kg)		Cancer Vol. 3, Pg. 124, 1950.