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Diprophylline cas no:479-18-5

Synonyms: Theophylline,7-(2,3-dihydroxypropyl)- (8CI);7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine;7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione;7-(2,3-Dihydroxypropyl)theophylline;AFI-phyllin;Aristophyllin;Asthmolysin;Astmophysine;Athmolysin;Circain;Coronarin;Diphyllin;Diphylline;Diphylline (pharmaceutical);Diprofillin;Diprophyllin;Glyfyllin;Glyphyllin;Glyphylline;Hyphylline;Isophyllen;Lufyllin;NSC40844;Neophyl;Neostenovasan;Neothyllin;Neothylline;Neutrafil;Neutrafillina;Neutraphylline;Prophyllen;Protheophylline;Purifilin;Silbephylline;Solufilin;Solufyllin;Tefilan;Theal;Theal ampules;Thefulan;

Identification
NameDiprophylline
CAS479-18-5
SynonymsTheophylline,7-(2,3-dihydroxypropyl)- (8CI);7-(2,3-Dihydroxypropyl)-1,3-dimethylxanthine;7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione;7-(2,3-Dihydroxypropyl)theophylline;AFI-phyllin;Aristophyllin;Asthmolysin;Astmophysine;Athmolysin;Circain;Coronarin;Diphyllin;Diphylline;Diphylline (pharmaceutical);Diprofillin;Diprophyllin;Glyfyllin;Glyphyllin;Glyphylline;Hyphylline;Isophyllen;Lufyllin;NSC40844;Neophyl;Neostenovasan;Neothyllin;Neothylline;Neutrafil;Neutrafillina;Neutraphylline;Prophyllen;Protheophylline;Purifilin;Silbephylline;Solufilin;Solufyllin;Tefilan;Theal;Theal ampules;Thefulan;
EINECS(EC#)207-526-1
Molecular FormulaC10H14N4O4
Molecular Weight254.24
Chemical Properties
AppearanceWhite powder.
refractive index1.5403 (172 C)
storage tempStore in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Safety Data

Hazard Xn:Harmful
Risk R22
Safety

Safety Information of Diprophylline (CAS NO.479-18-5):
Hazard Codes: XnHarmful,XiIrritant
Risk Statements: 22-36/37/38??
R22:Harmful if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 36-36/37-26
S36:Wear suitable protective clothing.?
S36/37:Wear suitable protective clothing and gloves.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: XH5100000


Toxicity
1. ???

scu-rat LD50:1253?mg/kg

??? AEPPAE ?? Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 230 (1957),194.
2. ???

ivn-rat LD50:860?mg/kg

??? AEPPAE ?? Naunyn-Schmiedebergs Archiv fuer Experimentelle Pathologie und Pharmakologie. 230 (1957),194.
3. ???

orl-mus LD50:1954?mg/kg

??? JPETAB ?? Journal of Pharmacology and Experimental Therapeutics. 116 (1956),343.
4. ???

ipr-mus LD50:1052?mg/kg

??? ARZNAD ?? Arzneimittel-Forschung. Drug Research. 8 (1958),190.
5. ???

scu-mus LD50:120?mg/kg

??? ARZNAD ?? Arzneimittel-Forschung. Drug Research. 6 (1956),601.
6. ???

ivn-mus LD50:1080?mg/kg

??? RPOBAR ?? Research Progress in Organic Biological and Medicinal Chemistry. 2 (1970),288.

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