481-49-2|1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-, (14aS,26aR)-Products Supply

1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-, (14aS,26aR)- cas no:481-49-2

Synonyms: Cepharanthine(6CI,7CI,8CI);Oxyacanthan,6',12'-dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]-;(+)-Cepharanthine;1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,[14aS-(14aR*,26aS*)]-;Cepharantin;NSC 623442;O-Methylcepharanoline;

Identification

Name1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-, (14aS,26aR)-
CAS481-49-2
SynonymsCepharanthine(6CI,7CI,8CI);Oxyacanthan,6',12'-dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]-;(+)-Cepharanthine;1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,[14aS-(14aR*,26aS*)]-;Cepharantin;NSC 623442;O-Methylcepharanoline;
Molecular FormulaC₃₇H₃₈N₂O₆
Molecular Weight606.77

Chemical Properties

AppearanceYellow powder.
refractive index1.608
storage tempStore cool and dry in sealed containers.

Safety Data

Safety

Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	125mg/kg (125mg/kg)	?	Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 2413, 1976.
mouse	LD50	intravenous	43500ug/kg (43.5mg/kg)	behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: chronic pulmonary edema	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
mouse	LD50	oral	1900mg/kg (1900mg/kg)	skin and appendages (skin): hair: other	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
mouse	LD50	subcutaneous	100mg/kg (100mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat	LD50	intraperitoneal	> 155mg/kg (155mg/kg)	?	Drugs in Japan Vol. -, Pg. 648, 1995.
rat	LD50	intravenous	57mg/kg (57mg/kg)	behavioral: convulsions or effect on seizure threshold	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat	LD50	oral	2gm/kg (2000mg/kg)	behavioral: somnolence (general depressed activity) lungs,thorax, or respiration: chronic pulmonary edema	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
rat	LD50	subcutaneous	100mg/kg (100mg/kg)	?	Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.

supplier list

Canfo Chemical Co., Ltd.: Tel:; Address: No 9.Section 4 Renmin Nan Rd.Chengdu, 610041,P.R.China

Zhejiang Golden Pharma Co., Limited: Tel:+86-(571)-28887955; Address: 8F-B1,Season Mansion, No.98 Gudun Road, HangZhou, Zhejiang,

CFM Oskar Tropitzsch: Tel:+49-(9231)-9619-0; Address: Oskar Tropitzsch, Gaderstrasse 1, Marktredwitz D-95615,

Chengdu Biopurify Phytochemicals Ltd: Tel:+86-(28)-66780410; Address: No.24 Yongfeng Road, Chengdu, Sichuan 610041,

Aktin Chemicals, Inc.: Tel:+86-(28)-85159085; Address: Yongfeng Plaza, No.52, Yongfeng Road, Hi-tech Zone, Chengdu, Sichuan 610041,

APAC Pharmaceutical, LLC: Tel:+1-(410)-997-5552, 469-0727; Address: 6851 Oak Hall Lane, Suite 101, Columbia, Maryland 21045,

Conier Chem & Pharma Co.,Ltd.: Tel:+86-(23)-62922305; Address: 24 South Section 1, Yihuan Road, Chengdu, Sichuan 610065,

AOKChem Co., Ltd.: Tel:+86-(21)-50791030 / 68712331; Address: Room 203, Block D, No.333 Cailun Road, Zhangjiang High-tech Park, Shanghai 201203,

Shanghai Xunxin Chemical Co., Ltd: Tel:+86-(21)-38218795; Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315,

Fleton Natural Products Co., Ltd.: Tel:+86-(28)-8440-0798; Address: Floor 2, Huaxiang Mansion No 47, Huaishu Street, Chengdu,

Zhejiang Wonderful Pharma & Chem Co.: Tel:; Address:

Chemrio International Limited: Tel:+86-(574)-2789-1268, +86-13957895864; Address: Room 611-612 Wante Business Center, No.487 Yangmuqi Road, Hi-tech Park, Ningbo, Zhejiang 315040,

KINFON Pharmaceutical and Chemical Service: Tel:+86-(21)-58871570; Address: No.331, Dongyuan San Cun, 978# of Pudong South Rd., Shanghai 200120,

China Langchem Inc.: Tel:+86-(21)-58956006; Address: 514 Room, 1# Building, 88# Cailun Road, Zhangjiang High Tech Park, Shanghai 201203,

Kouting Chemical Co.,Ltd: Tel:+86-(21)-58116473; Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318,

1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-, (14aS,26aR)- cas no:481-49-2

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