1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-, (14aS,26aR)- cas no:481-49-2
Synonyms: Cepharanthine(6CI,7CI,8CI);Oxyacanthan,6',12'-dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]-;(+)-Cepharanthine;1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,[14aS-(14aR*,26aS*)]-;Cepharantin;NSC 623442;O-Methylcepharanoline;
Name1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-, (14aS,26aR)-
CAS481-49-2
SynonymsCepharanthine(6CI,7CI,8CI);Oxyacanthan,6',12'-dimethoxy-2,2'-dimethyl-6,7-[methylenebis(oxy)]-;(+)-Cepharanthine;1H-4,6:16,19-Dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2',3':17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline,2,3,13,14,14a,15,26,26a-octahydro-22,30-dimethoxy-1,14-dimethyl-,[14aS-(14aR*,26aS*)]-;Cepharantin;NSC 623442;O-Methylcepharanoline;
Molecular FormulaC37H38N2O6
Molecular Weight606.77
AppearanceYellow powder.
refractive index1.608
storage tempStore cool and dry in sealed containers.
Safety
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
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Organism
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Test Type
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Route
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Reported Dose (Normalized Dose)
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Effect
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Source
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mouse
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LD50
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intraperitoneal
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125mg/kg (125mg/kg)
|
?
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Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 2413, 1976.
|
mouse
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LD50
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intravenous
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43500ug/kg (43.5mg/kg)
|
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: chronic pulmonary edema
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Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
|
mouse
|
LD50
|
oral
|
1900mg/kg (1900mg/kg)
|
skin and appendages (skin): hair: other
|
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
|
mouse
|
LD50
|
subcutaneous
|
100mg/kg (100mg/kg)
|
?
|
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
|
rat
|
LD50
|
intraperitoneal
|
> 155mg/kg (155mg/kg)
|
?
|
Drugs in Japan Vol. -, Pg. 648, 1995.
|
rat
|
LD50
|
intravenous
|
57mg/kg (57mg/kg)
|
behavioral: convulsions or effect on seizure threshold
|
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
|
rat
|
LD50
|
oral
|
2gm/kg (2000mg/kg)
|
behavioral: somnolence (general depressed activity)
lungs,thorax, or respiration: chronic pulmonary edema
|
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
|
rat
|
LD50
|
subcutaneous
|
100mg/kg (100mg/kg)
|
?
|
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 3855, 1982.
|