Oxayohimban-16-carboxylicacid, 16,17-didehydro-19-methyl-, methyl ester, (19a)- cas no:483-04-5
Synonyms: Ajmalicine(7CI,8CI);Raubasine (6CI);(-)-Ajmalicine;4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylic acid,4a,5,7,8,13,13b,14,14a-octahydro-4-methyl-, methyl ester, (4S,4aR,13bS,14aS)-;Ajmalicin;Circolene;Hydrosarpan;Isoarteril;Lamuran;NSC 72133;NSC 95087;Py-tetrahydroserpentine;Ranitol;Raubaserp;Raubasil;Raubasin;Raumalina;Rauvasan;Sarpan;Tensyl;Tetrahydroserpentine;Vincain;Vincaine;Vincein;Vinceine;d-Yohimbine;
NameOxayohimban-16-carboxylicacid, 16,17-didehydro-19-methyl-, methyl ester, (19a)-
CAS483-04-5
SynonymsAjmalicine(7CI,8CI);Raubasine (6CI);(-)-Ajmalicine;4H-Indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylic acid,4a,5,7,8,13,13b,14,14a-octahydro-4-methyl-, methyl ester, (4S,4aR,13bS,14aS)-;Ajmalicin;Circolene;Hydrosarpan;Isoarteril;Lamuran;NSC 72133;NSC 95087;Py-tetrahydroserpentine;Ranitol;Raubaserp;Raubasil;Raubasin;Raumalina;Rauvasan;Sarpan;Tensyl;Tetrahydroserpentine;Vincain;Vincaine;Vincein;Vinceine;d-Yohimbine;
EINECS(EC#)207-589-5
Molecular FormulaC21H24N2O3
Molecular Weight352.47
refractive index1.656
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Risk R25
Safety Poison by ingestion, intraperitoneal, and intravenous routes. Human systemic effects by ingestion: general anesthesia, convulsions and lung effects. When heated to decomposition it emits highly toxic NOx. An antihypertensive agent and tranquilizer.
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AX7875000
- CHEMICAL NAME :
- Ajmalicine
- CAS REGISTRY NUMBER :
- 483-04-5
- BEILSTEIN REFERENCE NO. :
- 0097268
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C21-H24-N2-O3
- MOLECULAR WEIGHT :
- 352.47
- WISWESSER LINE NOTATION :
- T F6 D5 C666 EM ON SO TU&&TTTJ R1 UVO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 12500 ug/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CHETBF Chest. (American College of Chest Physicians, 911 Busse Hwy, Park
Ridge, IL 60068) V.57- 1970- Volume(issue)/page/year: 76,97,1979
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 233,72,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,117,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 24 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,117,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,117,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 165 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,117,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 233,72,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,117,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and
D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,117,1972
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 23,600,1973
