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9H-Pyrido[3,4-b]indole,1-methyl- cas no:486-84-0

Synonyms: 2,9-Pyridindole,1-methyl- (3CI); 1-Methyl-9H-pyrido[3,4-b]indole; 1-Methyl-b-carboline; Aribin; Aribine;Harman; Harmane; Indoter; Locuturin; Locuturine; NSC 54439; Zygofabagine

Identification
Name9H-Pyrido[3,4-b]indole,1-methyl-
CAS486-84-0
Synonyms2,9-Pyridindole,1-methyl- (3CI); 1-Methyl-9H-pyrido[3,4-b]indole; 1-Methyl-b-carboline; Aribin; Aribine;Harman; Harmane; Indoter; Locuturin; Locuturine; NSC 54439; Zygofabagine
EINECS(EC#)207-642-2
Molecular FormulaC12H10 N2
Molecular Weight182.24
Chemical Properties
refractive index1.75
storage tempStore at RT
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xn: Harmful;
Risk 20/21
Safety

Poison by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.Safety information of 1-Methyl-9H-pyrido[3,4-b]indole (CAS NO.486-84-0):
Hazard Codes  HarmfulXn,Xi
Risk Statements 
20/21 Harmful by inhalation and in contact with skin
36/37/38 Irritating to eyes, respiratory system and skin
Safety Statements 
22 Do not breathe dust
24/25 Avoid contact with skin and eyes
36 Wear suitable protective clothing
RIDADR  1544
WGK Germany  3
RTECS  UV0280000
HazardClass  6.1(b)
PackingGroup  III


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 50mg/kg (50mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 164, 1964.
rabbit LD50 subcutaneous 200mg/kg (200mg/kg)   Psychopharmacology Service Center, Bulletin. Vol. 2, Pg. 17, 1963.

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