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carvacrol cas no:499-75-2

Synonyms: 5-Isopropyl-2-methylphenol; Isothymol,95%; Isothymol

Identification
Namecarvacrol
CAS499-75-2
Synonyms5-Isopropyl-2-methylphenol; Isothymol,95%; Isothymol
EINECS(EC#)207-889-6
Molecular FormulaC10H14O
Molecular Weight150.22
Chemical Properties
AppearanceColorless or pale yellow liquid
refractive indexn20/D 1.522(lit.)
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass8
Safety Data

Hazard C:Corrosive
Risk R22;R34
Safety

Hazard Codes:?CorrosiveC
Risk Statements: 22-34?
R22:Harmful if swallowed.?
R34:Causes burns.
Safety Statements: 26-36/37/39-45?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3265 8/PG 3
WGK Germany: 3
RTECS: FI1225000
HazardClass: 8
PackingGroup: III
Hazardous Substances Data: 499-75-2(Hazardous Substances Data)


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 100mg/kg (100mg/kg) ? "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 46, 1959.
dog LDLo intravenous 310mg/kg (310mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Therapie. Vol. 3, Pg. 109, 1948.
frog LDLo subcutaneous 75mg/kg (75mg/kg) ? "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 46, 1959.
mouse LD50 intraperitoneal 73300ug/kg (73.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Quarterly Journal of Crude Drug Research. Vol. 19, Pg. 1, 1981.
mouse LD50 intravenous 80mg/kg (80mg/kg) BEHAVIORAL: SLEEP Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
mouse LD50 subcutaneous 680mg/kg (680mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Sapporo Igaku Zasshi. Sapporo Medical Journal. Vol. 3, Pg. 73, 1952.
rabbit LDLo oral 100mg/kg (100mg/kg) ? Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 161, Pg. 196, 1931.
rabbit LDLo skin 2700mg/kg (2700mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.
rabbit LDLo subcutaneous 1gm/kg (1000mg/kg) ? "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 46, 1959.
rat LD50 oral 810mg/kg (810mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

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Chemner Pharma
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