Dexamethasone cas no:50-02-2
Synonyms: 9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione; 9-alpha-fluoro-16-alpha-methylprednisolone; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
NameDexamethasone
CAS50-02-2
Synonyms9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione; 9-alpha-fluoro-16-alpha-methylprednisolone; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione
EINECS(EC#)200-003-9
Molecular FormulaC22H29FO5
Molecular Weight392.46
AppearanceWhite crystalline solid
alpha75 o (C=1, DIOXANE)
refractive index1.591
storage temp2-8°C
Hazard Xn:Harmful
Risk R40
Safety
Hazard Codes:?Xi,Xn
Risk Statements: 43-40-36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R40:Limited evidence of a carcinogenic effect.?
R43:May cause sensitization by skin contact.
Safety Statements: 36/37-45-36-26-22
S22:Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.?
S36/37:Wear suitable protective clothing and gloves.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| mouse |
LD50 |
intraperitoneal |
410mg/kg (410mg/kg) |
? |
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 281, 1970. |
| mouse |
LD50 |
subcutaneous |
4400mg/kg (4400mg/kg) |
? |
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979. |
| rabbit |
LD50 |
subcutaneous |
7200ug/kg (7.2mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" |
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. |
| rat |
LD50 |
intraperitoneal |
54mg/kg (54mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. |
| rat |
LD50 |
oral |
> 3gm/kg (3000mg/kg) |
? |
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 687, 1984. |
| rat |
LD50 |
subcutaneous |
14mg/kg (14mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. |
| women |
TDLo |
multiple routes |
4759ug/kg/18D (4.759mg/kg) |
KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED |
Intensive Care Medicine. Vol. 21, Pg. 238, 1995.
? |
