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Hazard Xn
Risk 22-36/37/38
Safety
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, hemorrhage, changes in teeth and supporting structures. Human mutation data reported. An experimental teratogen. An FDA proprietary drug used as an anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 2
1. |
cyt-hmn:leu 1 mg/L |
AJOGAH American Journal of Obstetrics and Gynecology. 116 (1973),867. | ||
2. |
orl-wmn TDLo:1100 mg/kg:CNS,BLD,MSK |
JAMAAP JAMA, Journal of the American Medical Association. 138 (1949),498. | ||
3. |
orl-rat LD50:850 mg/kg |
27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,263. | ||
4. |
ipr-rat LDLo:270 mg/kg |
MEIEDD Merck Index. 11 (1989),919. | ||
5. |
orl-mus LD50:440 mg/kg |
CKFRAY Ceskoslovenska Farmacie. 4 (1955),333. | ||
6. |
ipr-mus LD50:317 mg/kg |
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 156 (1965),261. | ||
7. |
orl-cat LD50:190 mg/kg |
27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,263. | ||
8. |
orl-rbt LD50:430 mg/kg |
27ZIAQ Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,151. | ||
9. |
orl-gpg LD50:380 mg/kg |
27ZQAG Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,263. |
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