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2,4-Imidazolidinedione,5-ethyl-3-methyl-5-phenyl- cas no:50-12-4

Synonyms: Hydantoin,5-ethyl-3-methyl-5-phenyl- (6CI,7CI,8CI);3-Ethylnirvanol;3-Methyl-5-ethyl-5-phenyl-2,4-imidazolidinedione;3-Methyl-5-ethyl-5-phenylhydantoin;5-Ethyl-3-methyl-5-phenyl-2,4(3H,5H)-imidazoledione;5-Ethyl-3-methyl-5-phenylhydantoin;5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dione;DL-Mephenytoin;Epiazin;Epilan;Fenantoin;Gerot-Epilan;Insulton;Mephenytoin;Mesantoin;Mesdontoin;Mesontoin;Methoin;Methylphenetoin;Metydan;NSC 34652;Phenantoin;Phenylethylmethylhydantoin;Sacerno;Sedantional;Sedantoin;Triantoin;

Identification
Name2,4-Imidazolidinedione,5-ethyl-3-methyl-5-phenyl-
CAS50-12-4
SynonymsHydantoin,5-ethyl-3-methyl-5-phenyl- (6CI,7CI,8CI);3-Ethylnirvanol;3-Methyl-5-ethyl-5-phenyl-2,4-imidazolidinedione;3-Methyl-5-ethyl-5-phenylhydantoin;5-Ethyl-3-methyl-5-phenyl-2,4(3H,5H)-imidazoledione;5-Ethyl-3-methyl-5-phenylhydantoin;5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dione;DL-Mephenytoin;Epiazin;Epilan;Fenantoin;Gerot-Epilan;Insulton;Mephenytoin;Mesantoin;Mesdontoin;Mesontoin;Methoin;Methylphenetoin;Metydan;NSC 34652;Phenantoin;Phenylethylmethylhydantoin;Sacerno;Sedantional;Sedantoin;Triantoin;
EINECS(EC#)200-012-8
Molecular FormulaC12H14 N2 O2
Molecular Weight218.28
Chemical Properties
storage temp2-8°C
Safety Data

Hazard Xn
Risk 22-36/37/38
Safety

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, hemorrhage, changes in teeth and supporting structures. Human mutation data reported. An experimental teratogen. An FDA proprietary drug used as an anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: HarmfulXn
Risk Statements: 22-36/37/38 
R22: Harmful if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 2


Toxicity
1.    

cyt-hmn:leu 1 mg/L

    AJOGAH    American Journal of Obstetrics and Gynecology. 116 (1973),867.
2.    

orl-wmn TDLo:1100 mg/kg:CNS,BLD,MSK

    JAMAAP    JAMA, Journal of the American Medical Association. 138 (1949),498.
3.    

orl-rat LD50:850 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,263.
4.    

ipr-rat LDLo:270 mg/kg

    MEIEDD    Merck Index. 11 (1989),919.
5.    

orl-mus LD50:440 mg/kg

    CKFRAY    Ceskoslovenska Farmacie. 4 (1955),333.
6.    

ipr-mus LD50:317 mg/kg

    AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 156 (1965),261.
7.    

orl-cat LD50:190 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,263.
8.    

orl-rbt LD50:430 mg/kg

    27ZIAQ    Drug Dosages in Laboratory Animals-A Handbook C.D. Barnes andL.G. Eltherington,Berkeley, CA.: Univ. of California Press,1973,151.
9.    

orl-gpg LD50:380 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,263.

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