cat |
LDLo |
intraperitoneal |
50mg/kg (50mg/kg) |
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 431, 1982. |
child |
TDLo |
oral |
2500ug/kg (2.5mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
American Journal of Diseases of Children. Vol. 140, Pg. 1094, 1986. |
dog |
LDLo |
intraperitoneal |
50mg/kg (50mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 431, 1982. |
dog |
LDLo |
intravenous |
11mg/kg (11mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 191, 1965. |
domestic animals - goat/sheep |
LD50 |
intravenous |
45100ug/kg (45.1mg/kg) |
CARDIAC: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
LIVER: OTHER CHANGES |
Dongbei Nongxueyuan Xuebao. Journal of Northeast Agricultural College. Vol. 34, Pg. 56, 1980. |
guinea pig |
LDLo |
intraperitoneal |
200mg/kg (200mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: ATAXIA
BEHAVIORAL: MUSCLE WEAKNESS |
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 431, 1982. |
hamster |
LD10 |
parenteral |
110mg/kg (110mg/kg) |
? |
Journal of Surgical Oncology. Vol. 15, Pg. 355, 1980. |
hamster |
LD50 |
intraperitoneal |
429mg/kg (429mg/kg) |
? |
Cancer Letters Vol. 2, Pg. 267, 1977. |
hamster |
LD50 |
oral |
763mg/kg (763mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: MUSCLE WEAKNESS
BEHAVIORAL: ATAXIA |
Experientia. Vol. 37, Pg. 401, 1981. |
human |
TDLo |
oral |
20mg/kg (20mg/kg) |
GASTROINTESTINAL: OTHER CHANGES
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Arthritis and Rheumatism. Vol. 12, Pg. 663, 1969. |
man |
LDLo |
multiple routes |
45mg/kg/26W-I (45mg/kg) |
BLOOD: OTHER CHANGES |
American Journal of the Medical Sciences. Vol. 254, Pg. 48, 1967. |
man |
TDLo |
oral |
56mg/kg/26D-I (56mg/kg) |
BLOOD: AGRANULOCYTOSIS |
American Journal of Medicine. Vol. 81, Pg. 1059, 1986. |
man |
TDLo |
oral |
56mg/kg/4W-I (56mg/kg) |
LIVER: OTHER CHANGES |
Southern Medical Journal. Vol. 78, Pg. 222, 1985. |
man |
TDLo |
oral |
579mg/kg/2Y-I (579mg/kg) |
LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
LIVER: LIVER FUNCTION TESTS IMPAIRED
LIVER: OTHER CHANGES |
American Journal of Gastroenterology. Vol. 95, Pg. 845, 2000. |
monkey |
LDLo |
intravenous |
45mg/kg (45mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE |
Cancer Chemotherapy Reports, Part 2. Vol. 2, Pg. 191, 1965. |
mouse |
LD50 |
intraperitoneal |
110mg/kg (110mg/kg) |
? |
Farmakologiya i Toksikologiya Vol. 41, Pg. 90, 1978. |
mouse |
LD50 |
intravenous |
140mg/kg (140mg/kg) |
? |
"Radiation-Induced Cancer, Proceedings of a Symposium, Athens, 1969," Lanham, MD, Bernan-UNIPUB, 1969Vol. -, Pg. 97, 1969. |
mouse |
LD50 |
oral |
137mg/kg (137mg/kg) |
? |
Russian Pharmacology and Toxicology Vol. 36, Pg. 240, 1973. |
mouse |
LD50 |
parenteral |
315mg/kg (315mg/kg) |
? |
Transplantation. Vol. 13, Pg. 316, 1972. |
mouse |
LD50 |
subcutaneous |
200mg/kg (200mg/kg) |
? |
Advances in the Study of Birth Defects. Vol. 2, Pg. 95, 1979. |
mouse |
LD50 |
unreported |
480mg/kg (480mg/kg) |
? |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(4), Pg. 157S, 1968. |
mouse |
LDLo |
intratracheal |
200mg/kg (200mg/kg) |
? |
Toxicology Letters. Vol. 30, Pg. 63, 1986. |
rabbit |
LDLo |
intraperitoneal |
200mg/kg (200mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 431, 1982. |
rabbit |
LDLo |
intravenous |
300mg/kg (300mg/kg) |
? |
Journal of Toxicological Sciences. Vol. 34, Pg. 308, 1999. |
rat |
LD50 |
intracrebral |
> 400ug/kg (0.4mg/kg) |
? |
Journal of Pharmacy and Pharmacology. Vol. 18, Pg. 760, 1966. |
rat |
LD50 |
intraperitoneal |
40mg/kg (40mg/kg) |
? |
Clinical Proceedings of the Children's Hospital of the District of Columbia. Vol. 18, Pg. 307, 1962. |
rat |
LD50 |
intravenous |
148mg/kg (148mg/kg) |
BLOOD: NORMOCYTIC ANEMIA |
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 431, 1982. |
rat |
LD50 |
oral |
100mg/kg (100mg/kg) |
? |
Drugs in Japan Vol. -, Pg. 516, 1995. |
rat |
LD50 |
subcutaneous |
144mg/kg (144mg/kg) |
BLOOD: NORMOCYTIC ANEMIA |
Kiso to Rinsho. Clinical Report. Vol. 16, Pg. 431, 1982. |
rat |
LD50 |
unreported |
190mg/kg (190mg/kg) |
? |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 64(4), Pg. 157S, 1968. |
women |
LDLo |
oral |
16mg/kg/4D-I (16mg/kg) |
BLOOD: OTHER CHANGES |
American Journal of the Medical Sciences. Vol. 254, Pg. 48, 1967. |
women |
TDLo |
intravenous |
13500ug/kg (13.5mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE |
Annals of Internal Medicine. Vol. 116, Pg. 92, 1992. |
women |
TDLo |
intravenous |
60mg/kg/9W-I (60mg/kg) |
? |
Archives of Internal Medicine. Vol. 145, Pg. 548, 1985. |
women |
TDLo |
oral |
45mg/kg (45mg/kg) |
KIDNEY, URETER, AND BLADDER: OTHER CHANGES |
Arthritis and Rheumatism. Vol. 15, Pg. 530, 1972. |