Predonin cas no:50-24-8
Synonyms: Supercortisol;Codelcortone;Prestwick_404;Precortancyl;Cortalone;Dydeltrone;Fernisolone;Meti-Derm;Donisolone;K 1557;Paracortol;Cotogesic;Paracotol;Precortilon;Sterolone;Delcortol;Rolisone;Precortalon;Hydrodeltalone;Delta-Ef-Cortelan;Delta-cortef (TN);component of Ataraxoid;Prenolone;Cordrol;Hydeltra;(8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;Meticortelone;Deltacortenol;Sterane;Delta F;Precortisyl;Ulacort;Meticortelone;Sterolone;Deltisilone;Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-;Decortin H;1-Dehydrohydrocortisone;Prednis;Pregna-1,4-diene-3,20-dione,11,17,21- trihydroxy-,(11a)-;Predonine;Lentosone;1, 2-Dehydrohydrocortisone;Hydroretrocortin;Deltacortril;Di-Adreson F;Derpo PD;Deltahydrocortisone;Dexa-Cortidelt Hostacortin H;Hostacortin H;Scherisolon;Hydrodeltisone;Metacortandralone;Ultracortene-H;Ultracorten H;Fernisolone P;Prednisolone;
NamePredonin
CAS50-24-8
SynonymsSupercortisol;Codelcortone;Prestwick_404;Precortancyl;Cortalone;Dydeltrone;Fernisolone;Meti-Derm;Donisolone;K 1557;Paracortol;Cotogesic;Paracotol;Precortilon;Sterolone;Delcortol;Rolisone;Precortalon;Hydrodeltalone;Delta-Ef-Cortelan;Delta-cortef (TN);component of Ataraxoid;Prenolone;Cordrol;Hydeltra;(8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;Meticortelone;Deltacortenol;Sterane;Delta F;Precortisyl;Ulacort;Meticortelone;Sterolone;Deltisilone;Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-;Decortin H;1-Dehydrohydrocortisone;Prednis;Pregna-1,4-diene-3,20-dione,11,17,21- trihydroxy-,(11a)-;Predonine;Lentosone;1, 2-Dehydrohydrocortisone;Hydroretrocortin;Deltacortril;Di-Adreson F;Derpo PD;Deltahydrocortisone;Dexa-Cortidelt Hostacortin H;Hostacortin H;Scherisolon;Hydrodeltisone;Metacortandralone;Ultracortene-H;Ultracorten H;Fernisolone P;Prednisolone;
EINECS(EC#)200-021-7
Molecular FormulaC21H28O5
Molecular Weight360.44402
AppearanceCrystalline Solid
refractive index1.587
storage temp-20°C Freezer
Hazard Xn:Harmful
Risk R22
Safety
A poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects by an unspecified route: developmental abnormalities of the central nervous system; effects on embryo or fetus: fetal death, extra embryonic structures. Human reproductive effects by an unspecified route: stillbirth. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:??Xn,C,F
Risk Statements:? 22-34-11?
R22:Harmful if swallowed.?
R34:Causes burns.?
R11:Highly flammable.
Safety Statements:? 22-45-36/37/39-26-16?
S22:Do not breathe dust.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S16:Keep away from sources of ignition.
WGK Germany:? 3
RTECS:? TU4152000
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| man |
TDLo |
oral |
9mg/kg/2W-I (9mg/kg) |
BEHAVIORAL: TOXIC PSYCHOSIS |
Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984. |
| mouse |
LD50 |
intraperitoneal |
65mg/kg (65mg/kg) |
? |
Indian Drugs. Vol. 22, Pg. 529, 1985. |
| mouse |
LD50 |
intravenous |
180mg/kg (180mg/kg) |
? |
Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982. |
| mouse |
LD50 |
oral |
1680mg/kg (1680mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 111, 1970. |
| mouse |
LD50 |
subcutaneous |
> 3500mg/kg (3500mg/kg) |
? |
Drugs in Japan Vol. 6, Pg. 710, 1982. |
| rat |
LD50 |
intraperitoneal |
2gm/kg (2000mg/kg) |
? |
Advances in Teratology. Vol. 3, Pg. 181, 1968. |
| rat |
LD50 |
intravenous |
120mg/kg (120mg/kg) |
? |
Pharmaceutical Chemistry Journal Vol. 16, Pg. 63, 1982. |
| rat |
LD50 |
subcutaneous |
147mg/kg (147mg/kg) |
? |
Toxicology and Applied Pharmacology. Vol. 8, Pg. 250, 1966. |
| women |
TDLo |
oral |
14mg/kg/13D-I (14mg/kg) |
BEHAVIORAL: TOXIC PSYCHOSIS |
Drug Intelligence and Clinical Pharmacy. Vol. 18, Pg. 603, 1984. |
