50-33-9|4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidineProducts Supply

4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine cas no:50-33-9

Synonyms: 1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine;1,2-Diphenyl-3,5-dioxo-4-n-butylpyrazolidine;1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione;3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine;

Identification

Name4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine
CAS50-33-9
Synonyms1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine;1,2-Diphenyl-3,5-dioxo-4-n-butylpyrazolidine;1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione;3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine;
EINECS(EC#)200-029-0
Molecular FormulaC₁₉H₂₀N₂O₂
Molecular Weight308.38

Chemical Properties

Appearanceoff-white powder
storage temp-20°C Freezer

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T:Toxic
Risk R45;R20/21/22;R36/37/38;R42/43
Safety

Hazard Codes:?Xn,T
Risk Statements: 36/37/38-20/21/22-42/43-45
R36/37/38:Irritating to eyes, respiratory system and skin.?
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.?
R42/43:May cause sensitization by inhalation and skin contact.?
R45:May cause cancer.
Safety Statements: 36/37/39-26-45-22-53
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)?
S22:Do not breathe dust.?
S53:Avoid exposure - obtain special instructions before use.
RIDADR: 3249
RTECS: UQ8225000
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 50-33-9(Hazardous Substances Data)
Suspected human carcinogen producing leukemia. A human poison by parenteral route. An experimental poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Human systemic effects by ingestion and possibly other routes: fever, blood pressure increase, other unspecified vascular effects, damage to kidney tubules and glomeruli, decreased urine volume, blood in the urine, reduction in the number of white blood cells, and agranulocytosis. Experimental teratogenic and reproductive effects. Human mutation data reported. An eye irritant. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intravenous	100mg/kg (100mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
dog	LD50	intravenous	121mg/kg (121mg/kg)	BEHAVIORAL: ANALGESIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.
dog	LD50	oral	332mg/kg (332mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 265, 1980.
guinea pig	LD50	oral	250mg/kg (250mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1207, 1969.
hamster	LD50	oral	1260mg/kg (1260mg/kg)	?	Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.
mammal (species unspecified)	LD50	intraperitoneal	300mg/kg (300mg/kg)	BEHAVIORAL: ANALGESIA	European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 21, Pg. 277, 1986.
mammal (species unspecified)	LD50	oral	700mg/kg (700mg/kg)	BEHAVIORAL: ANALGESIA	European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 21, Pg. 277, 1986.
man	TDLo	oral	17500ug/kg/3W (17.5mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Annals of Internal Medicine. Vol. 41, Pg. 1075, 1954.
man	TDLo	oral	2426mg/kg/24H (2426mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Annals of Emergency Medicine. Vol. 20, Pg. 204, 1991.
man	TDLo	unreported	200mg/kg/5W-I (200mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED KIDNEY, URETER, AND BLADDER: HEMATURIA	British Medical Journal. Vol. 282, Pg. 950, 1981.
mouse	LD50	intramuscular	430mg/kg (430mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 97, 1977.
mouse	LD50	intraperitoneal	128mg/kg (128mg/kg)	?	Pharmaceutical Chemistry Journal Vol. 19, Pg. 33, 1985.
mouse	LD50	intravenous	90mg/kg (90mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969.
mouse	LD50	oral	238mg/kg (238mg/kg)	?	Pharmacological Research Communications. Vol. 18, Pg. 241, 1986.
mouse	LD50	subcutaneous	230mg/kg (230mg/kg)	?	Journal of Pharmacy and Pharmacology. Vol. 7, Pg. 1022, 1955.
mouse	LD50	unreported	128mg/kg (128mg/kg)	?	Farmatsevtichnii Zhurnal Vol. (5), Pg. 26, 1983.
rabbit	LD50	intravenous	146mg/kg (146mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 129, 1960.
rabbit	LD50	oral	781mg/kg (781mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 265, 1980.
rat	LD50	intramuscular	220mg/kg (220mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 665, 1960.
rat	LD50	intraperitoneal	142mg/kg (142mg/kg)	?	Farmaco, Edizione Scientifica. Vol. 14, Pg. 347, 1959.
rat	LD50	intravenous	100mg/kg (100mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 665, 1960.
rat	LD50	oral	245mg/kg (245mg/kg)	BEHAVIORAL: ANALGESIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 123, Pg. 48, 1959.
rat	LD50	subcutaneous	230mg/kg (230mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR	Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1285, 1972.
women	TDLo	oral	168mg/kg/4W-I (168mg/kg)	VASCULAR: OTHER CHANGES KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI	Archives of Internal Medicine. Vol. 145, Pg. 685, 1985.
women	TDLo	unreported	40mg/kg/4D-I (40mg/kg)	BLOOD: LEUKOPENIA BLOOD: AGRANULOCYTOSIS	Problemy Gematologii i Perelivaniia Krovi. Problems of Hematology and Blood Transfusion. Vol. 4(5), Pg. 48, 1959.

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4-Butyl-1,2-diphenyl-3,5-dioxopyrazolidine cas no:50-33-9

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