cat |
LD50 |
intravenous |
100mg/kg (100mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969. |
dog |
LD50 |
intravenous |
121mg/kg (121mg/kg) |
BEHAVIORAL: ANALGESIA |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. |
dog |
LD50 |
oral |
332mg/kg (332mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 265, 1980. |
guinea pig |
LD50 |
oral |
250mg/kg (250mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1207, 1969. |
hamster |
LD50 |
oral |
1260mg/kg (1260mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
mammal (species unspecified) |
LD50 |
intraperitoneal |
300mg/kg (300mg/kg) |
BEHAVIORAL: ANALGESIA |
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 21, Pg. 277, 1986. |
mammal (species unspecified) |
LD50 |
oral |
700mg/kg (700mg/kg) |
BEHAVIORAL: ANALGESIA |
European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 21, Pg. 277, 1986. |
man |
TDLo |
oral |
17500ug/kg/3W (17.5mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED |
Annals of Internal Medicine. Vol. 41, Pg. 1075, 1954. |
man |
TDLo |
oral |
2426mg/kg/24H (2426mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Annals of Emergency Medicine. Vol. 20, Pg. 204, 1991. |
man |
TDLo |
unreported |
200mg/kg/5W-I (200mg/kg) |
VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
KIDNEY, URETER, AND BLADDER: HEMATURIA |
British Medical Journal. Vol. 282, Pg. 950, 1981. |
mouse |
LD50 |
intramuscular |
430mg/kg (430mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 97, 1977. |
mouse |
LD50 |
intraperitoneal |
128mg/kg (128mg/kg) |
? |
Pharmaceutical Chemistry Journal Vol. 19, Pg. 33, 1985. |
mouse |
LD50 |
intravenous |
90mg/kg (90mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 36, 1969. |
mouse |
LD50 |
oral |
238mg/kg (238mg/kg) |
? |
Pharmacological Research Communications. Vol. 18, Pg. 241, 1986. |
mouse |
LD50 |
subcutaneous |
230mg/kg (230mg/kg) |
? |
Journal of Pharmacy and Pharmacology. Vol. 7, Pg. 1022, 1955. |
mouse |
LD50 |
unreported |
128mg/kg (128mg/kg) |
? |
Farmatsevtichnii Zhurnal Vol. (5), Pg. 26, 1983. |
rabbit |
LD50 |
intravenous |
146mg/kg (146mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 129, 1960. |
rabbit |
LD50 |
oral |
781mg/kg (781mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Oyo Yakuri. Pharmacometrics. Vol. 20, Pg. 265, 1980. |
rat |
LD50 |
intramuscular |
220mg/kg (220mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 665, 1960. |
rat |
LD50 |
intraperitoneal |
142mg/kg (142mg/kg) |
? |
Farmaco, Edizione Scientifica. Vol. 14, Pg. 347, 1959. |
rat |
LD50 |
intravenous |
100mg/kg (100mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 665, 1960. |
rat |
LD50 |
oral |
245mg/kg (245mg/kg) |
BEHAVIORAL: ANALGESIA |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 123, Pg. 48, 1959. |
rat |
LD50 |
subcutaneous |
230mg/kg (230mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: TREMOR |
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1285, 1972. |
women |
TDLo |
oral |
168mg/kg/4W-I (168mg/kg) |
VASCULAR: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI |
Archives of Internal Medicine. Vol. 145, Pg. 685, 1985. |
women |
TDLo |
unreported |
40mg/kg/4D-I (40mg/kg) |
BLOOD: LEUKOPENIA
BLOOD: AGRANULOCYTOSIS |
Problemy Gematologii i Perelivaniia Krovi. Problems of Hematology and Blood Transfusion. Vol. 4(5), Pg. 48, 1959. |