50-35-1|thalidomideProducts Supply - Chemical intermediates Network

thalidomide cas no:50-35-1

Synonyms: 2-phthalimidoglutarimide; 2-(2,6-dioxo-3-piperidinyl)-1h-isoindole-1,3(2h)-dione

Identification

Namethalidomide
CAS50-35-1
Synonyms2-phthalimidoglutarimide; 2-(2,6-dioxo-3-piperidinyl)-1h-isoindole-1,3(2h)-dione
EINECS(EC#)200-031-1
Molecular FormulaC13H10N2O4
Molecular Weight258.23

Chemical Properties

Appearancewhite solid
refractive index1.646
storage tempStore at RT

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T:Toxic
Risk R46;R61;R21;R25;R62
Safety

Safety Information of? Thalidomide (CAS NO.50-35-1):
Hazard Codes: T
Risk Statements: 46-61-21-25-62?
R46:May cause heritable genetic damage.?
R61:May cause harm to the unborn child.?
R21:Harmful in contact with skin.?
R25 :Toxic if swallowed.?
R62:Risk of impaired fertility.
Safety Statements: 53-22-26-36/37/39-45
S53:Avoid exposure - obtain special instructions before use.?
S22:Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: TI4375000
HazardClass: 6.1(b)
PackingGroup: III
Poison by ingestion. Moderately toxic by skin contact and intraperitoneal routes. Human teratogenic effects by ingestion: developmental abnormalities of the musculoskeletal and cardiovascular systems. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic and teratogenic data. Human mutation data reported. It was commonly used as a prescription drug in Europe in the late 1950s and early 1960s. Its use was discontinued because it was discovered to cause serious congenital abnormalities in the fetus, notably amelia and phocomelia (absence or deformity of the limbs, including hands and feet) when taken by a woman during early pregnancy. When heated to decomposition it emits toxic fumes of NO_x. Used as a sedative and hypnotic.

Toxicity

1.	???	cyt-hmn:lym 1?mg/L	???	AMSVAZ ?? Acta Medica Scandinavica. 177 (1965),783.
2.	???	dns-rat-ipr 80?mg/kg	???	JPETAB ?? Journal of Pharmacology and Experimental Therapeutics. 171 (1970),109.
3.	???	orl-rat LD50:113?mg/kg	???	TXAPA9 ?? Toxicology and Applied Pharmacology. 14 (1969),515.
4.	???	skn-rat LD50:1550?mg/kg	???	TXAPA9 ?? Toxicology and Applied Pharmacology. 14 (1969),515.
5.	???	orl-mus LD50:2000?mg/kg	???	LIFSAK ?? Life Sciences. 3 (1964),721.
6.	???	ipr-mus LDLo:800?mg/kg	???	TXAPA9 ?? Toxicology and Applied Pharmacology. 23 (1972),288.

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thalidomide cas no:50-35-1

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