50-42-0|Benzeneacetic acid, α-phenyl-, 2-(diethylamino)ethylester, hydrochloride (1:1)Products Supply

Benzeneacetic acid, α-phenyl-, 2-(diethylamino)ethylester, hydrochloride (1:1) cas no:50-42-0

Synonyms: Aceticacid, diphenyl-, 2-(diethylamino)ethyl ester hydrochloride (8CI);Benzeneaceticacid, a-phenyl-, 2-(diethylamino)ethylester, hydrochloride (9CI);2-Diethylaminoethyl diphenylacetate hydrochloride;Adifenin hydrochloride;Adiphen hydrochloride;Difacil hydrochloride;Diphacil hydrochloride;NSC 129224;Patrovina;Paxil (anticholinergic);Sentiv;Spasmolytin;Spasmolytin hydrochloride;Spasnil;Trasentin hydrochloride;Trasentine hydrochloride;Vegantin;β-Diethylaminoethyldiphenylacetate hydrochloride;

Identification

NameBenzeneacetic acid, α-phenyl-, 2-(diethylamino)ethylester, hydrochloride (1:1)
CAS50-42-0
SynonymsAceticacid, diphenyl-, 2-(diethylamino)ethyl ester hydrochloride (8CI);Benzeneaceticacid, a-phenyl-, 2-(diethylamino)ethylester, hydrochloride (9CI);2-Diethylaminoethyl diphenylacetate hydrochloride;Adifenin hydrochloride;Adiphen hydrochloride;Difacil hydrochloride;Diphacil hydrochloride;NSC 129224;Patrovina;Paxil (anticholinergic);Sentiv;Spasmolytin;Spasmolytin hydrochloride;Spasnil;Trasentin hydrochloride;Trasentine hydrochloride;Vegantin;β-Diethylaminoethyldiphenylacetate hydrochloride;
EINECS(EC#)200-036-9
Molecular FormulaC₂₀H₂₆ClNO₂
Molecular Weight347.88

Chemical Properties

AppearanceWhite or almost white powder

Safety Data

Hazard Xn:Harmful;
Risk R20/21/22

Toxicity

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH2625000

CHEMICAL NAME :: Acetic acid, diphenyl-, 2-(diethylamino)ethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 50-42-0

LAST UPDATED :: 199603

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C20-H25-N-O2.Cl-H

MOLECULAR WEIGHT :: 347.92

WISWESSER LINE NOTATION :: 2N2&2OVYR&R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 96,151,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,174,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 59,149,1938

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 185 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 82,23,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 630 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937- Volume(issue)/page/year: 33,145,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 96,151,1949

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intradermal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 59,149,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,365,1937

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,365,1937

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,365,1937

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BDCBAD Berichte der Deutschen Chemischen Gesellschaft. Abteilung B: Abhandlungen. (Heidelberg, Fed. Rep. Ger.) V.62-77, 1929-45. For publisher information, see CHBEAM. Volume(issue)/page/year: 72,1551,1939

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Lungs, Thorax, or Respiration - other changes

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 11,679,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Lungs, Thorax, or Respiration - other changes

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 11,679,1938

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes Cardiac - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 59,365,1937

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 14,731,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 11,679,1938

supplier list

Shanghai Longschem Co.,Ltd: Tel:; Address: Shanghai Jincheng Road 338 6# 1002 Room

Ji'nan Orgachem Pharmaceutical Co.,Ltd: Tel:86-531-82687810; Address: F9 No.2766 Yingxiu Road Gaoxin Zone

Chengdu Sino-Strong Pharmaceutical Co., Ltd.: Tel:+86-(28)-82783659; Address: 459 West Haike Road, Cross-Straits Technological Industry Park, Wenjiang District, Chengdu 611130,

Chemner Pharma: Tel:+86-(23)-62482345; Address: 668# International Exhibtion and Conference Center, Chongqing, Sichuan 400060,

Tecoland Corporation: Tel:+1-(732)-603-9577; Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,

Trust & We Co., Ltd.: Tel:86-21-61551611; Address: 601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong, Shanghai, China.

Conier Chem & Pharma Co.,Ltd.: Tel:+86-(23)-62922305; Address: 24 South Section 1, Yihuan Road, Chengdu, Sichuan 610065,

AOKChem Co., Ltd.: Tel:+86-(21)-50791030 / 68712331; Address: Room 203, Block D, No.333 Cailun Road, Zhangjiang High-tech Park, Shanghai 201203,

Tianjin Hi-Tesion Bio&Chem Co., Ltd.: Tel:+86-(22)-2372-5099; Address: C1506, Wanhao Mansion, No.333 Binshuixi Road, Nankai District, Tianjin 300381,

Chemrio International Limited: Tel:+86-(574)-2789-1268, +86-13957895864; Address: Room 611-612 Wante Business Center, No.487 Yangmuqi Road, Hi-tech Park, Ningbo, Zhejiang 315040,

Haihang Industry Co., Ltd.: Tel:+86-(531)-88032799; Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100,

Ronas Chemicals Ind. Co., Ltd.: Tel:+86-(28)-86082869; Address: Rome International Plaza,Room 09A,19th Floor,NO.210,West Yulong Street, Chengdu, Qingyang District, Sichuan 610072,

China Langchem Inc.: Tel:+86-(21)-58956006; Address: 514 Room, 1# Building, 88# Cailun Road, Zhangjiang High Tech Park, Shanghai 201203,

Daxinganling International Import&Export Co.,Ltd: Tel:86-452-6197139; Address: 5F,C Linandalijiang,Building No.25 ,9xinjiang Road ,Jianhua District

Hangzhou UNIWISE International Co.,Ltd.: Tel:+86-571-28819531; Address: E-19F, Dongqiing Building, 52 Qingchun Rd, Hangzhou, China

Benzeneacetic acid, α-phenyl-, 2-(diethylamino)ethylester, hydrochloride (1:1) cas no:50-42-0

Directory

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

supplier list