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6-Mercaptopurine cas no:50-44-2

Synonyms: 6-Mercaptopurinum;6-Mercaptopurine, >99%;NSC-755;Mercaleukin;Purine-6-thiol, monohydrate;6-mercapto-;9H-Purin-6-yl hydrosulfide;6-Thioxopurine;U-4748;Puri-Nethol;1,7-Dihydro-6H-purine-6-thione;6-Thiopurine;6H-Purine-6-thione, 1,7-dihydro-;7-Mercapto-1,3,4,6-tetrazaindene;Hypoxanthine, thio-;6-Purinethiol;Mercaleukim;7H-purine-6-thiol;

Identification
Name6-Mercaptopurine
CAS50-44-2
Synonyms6-Mercaptopurinum;6-Mercaptopurine, >99%;NSC-755;Mercaleukin;Purine-6-thiol, monohydrate;6-mercapto-;9H-Purin-6-yl hydrosulfide;6-Thioxopurine;U-4748;Puri-Nethol;1,7-Dihydro-6H-purine-6-thione;6-Thiopurine;6H-Purine-6-thione, 1,7-dihydro-;7-Mercapto-1,3,4,6-tetrazaindene;Hypoxanthine, thio-;6-Purinethiol;Mercaleukim;7H-purine-6-thiol;
EINECS(EC#)200-037-4
Molecular FormulaC5H4N4S
Molecular Weight152.17706
Chemical Properties
Appearanceyellow crystalline powder
refractive index1.828
storage tempStore at RT
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard UN NO.
Safety

Safety Information of?Mercaptopurine (CAS NO.50-44-2):
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III
Poison by ingestion, intraperitoneal, subcutaneous, parenteral, and intravenous routes. Human systemic effects by ingestion: dermatitis. Experimental teratogenic and reproductive effects. Questionable human carcinogen producing Hodgkin's disease and leukemia. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx. See also MERCAPTANS.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 intraperitoneal 364mg/kg (364mg/kg) ? Archives of Toxicology. Vol. 32, Pg. 1, 1974.
man TDLo oral 40mg/kg/1W-I (40mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 122, Pg. 1413, 1986.
mouse LD50 intraperitoneal 80mg/kg (80mg/kg) ? Cancer Research. Vol. 42, Pg. 122, 1982.
mouse LD50 intravenous 80mg/kg (80mg/kg) ? Cancer Research. Vol. 42, Pg. 122, 1982.
mouse LD50 oral 260mg/kg (260mg/kg) ? Cesko-Slovenska Farmacie. Vol. 14, Pg. 389, 1965.
mouse LD50 subcutaneous 100mg/kg (100mg/kg) IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASE IN HUMORAL IMMUNE RESPONSE Journal of Medicinal Chemistry. Vol. 18, Pg. 320, 1975.
rat LD50 intraperitoneal 159mg/kg (159mg/kg) ? Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 41, Pg. 571, 1984.
rat LD50 intravenous 250mg/kg (250mg/kg) ? Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970.
rat LD50 oral 277mg/kg (277mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 15, Pg. 1037, 1973.
rat LD50 parenteral 250mg/kg (250mg/kg) ? Recent Results in Cancer Research. Vol. 52, Pg. 76, 1975.
rat LD50 subcutaneous 90mg/kg (90mg/kg) ? Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 15, Pg. 1037, 1973.

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