5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N-methyl- cas no:50-47-5
Synonyms: 5H-Dibenz[b,f]azepine,10,11-dihydro-5-[3-(methylamino)propyl]- (6CI,8CI); 10,11-Dihydro-5-[3-(methylamino)propyl]-5-H-dibenz[b,f]azepine;DMI; DMI (pharmaceutical); Demethylimipramine; Desimipramine; Desipramin;Desipramine; Desmethylimipramine; Imipramine, demethyl-;Methylaminopropyliminodibenzyl; Monodemethylimipramine; N-Desmethylimipramine;Norimipramine
Name5H-Dibenz[b,f]azepine-5-propanamine,10,11-dihydro-N-methyl-
CAS50-47-5
Synonyms5H-Dibenz[b,f]azepine,10,11-dihydro-5-[3-(methylamino)propyl]- (6CI,8CI); 10,11-Dihydro-5-[3-(methylamino)propyl]-5-H-dibenz[b,f]azepine;DMI; DMI (pharmaceutical); Demethylimipramine; Desimipramine; Desipramin;Desipramine; Desmethylimipramine; Imipramine, demethyl-;Methylaminopropyliminodibenzyl; Monodemethylimipramine; N-Desmethylimipramine;Norimipramine
EINECS(EC#)200-040-0
Molecular FormulaC18H22 N2
Molecular Weight266.42
Hazard Xn: Harmful;
Risk R20/21/22
Safety
Human poison by ingestion. Experimental poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: degenerative brain changes, tremors, coma, and cyanosis. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. An antidepressant. Related to diazepam. When heated to decomposition it emits toxic fumes of NOx.Safety information of Desipramine (CAS NO.50-47-5):
Hazard Codes 
Xn
Risk Statements
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
Safety Statements
36 Wear suitable protective clothing
WGK Germany 3
| 1. |
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dnd-esc 20 µmol/L
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MUREAV Mutation Research. 89 (1981),95. |
| 2. |
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cyt-oin-unr 10 g/L
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JCLBA3 Journal of Cell Biology. 47 (1970),182a. |
| 3. |
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orl-wmn LDLo:30 mg/kg:BRN,CNS
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34ZIAG Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,201. |
| 4. |
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orl-chd LDLo:125 mg/kg:CNS,PUL
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PSYPAG Psychopharmacologia (Berlin). 10 (1967),431. |
| 5. |
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orl-hmn LDLo:30 mg/kg:CNS,BRN,PUL
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DMWOAX Deutsche Medizinische Wochenschrift. 93 (1968),117. |
| 6. |
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orl-rat LD50:375 mg/kg
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ARZNAD Arzneimittel-Forschung. Drug Research. 19 (1969),1617. |
| 7. |
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ipr-rat LD50:48 mg/kg
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ARZNAD Arzneimittel-Forschung. Drug Research. 20 (1970),1561. |
| 8. |
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scu-rat LD50:183 mg/kg
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ARZNAD Arzneimittel-Forschung. Drug Research. 20 (1970),1561. |
| 9. |
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ivn-rat LD50:29 mg/kg
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AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 148 (1964),560. |
| 10. |
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orl-mus LD50:448 mg/kg
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JJPAAZ Japanese Journal of Pharmacology. 21 (1971),47. |
