cat |
LDLo |
intravenous |
20mg/kg (20mg/kg) |
|
Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
cat |
LDLo |
oral |
100mg/kg (100mg/kg) |
|
Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. Vol. 114, Pg. 787, 1975. |
child |
LD50 |
oral |
40mg/kg (40mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: COMA |
Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980. |
child |
LDLo |
oral |
35mg/kg (35mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
CARDIAC: OTHER CHANGES |
Schweizerische Medizinische Wochenschrift. Vol. 99, Pg. 1157, 1969. |
child |
TDLo |
oral |
30mg/kg (30mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: ATAXIA |
American Journal of Diseases of Children. Vol. 130, Pg. 507, 1976. |
dog |
LDLo |
intravenous |
45mg/kg (45mg/kg) |
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Bollettino Chimico Farmaceutico. Vol. 112, Pg. 601, 1973. |
dog |
LDLo |
oral |
100mg/kg (100mg/kg) |
|
"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 78, 1972. |
human |
LD50 |
oral |
40mg/kg (40mg/kg) |
|
Proceedings of the European Society for the Study of Drug Toxicity. Vol. 6, Pg. 171, 1965. |
human |
LDLo |
oral |
450mg/kg (450mg/kg) |
SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE" |
British Medical Journal. Vol. 1, Pg. 722, 1979. |
mammal (species unspecified) |
LD50 |
oral |
350mg/kg (350mg/kg) |
BEHAVIORAL: ANTICONVULSANT |
Journal of Medicinal Chemistry. Vol. 8, Pg. 836, 1965. |
mammal (species unspecified) |
LD50 |
unreported |
455mg/kg (455mg/kg) |
|
Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(7), Pg. 27, 1990. |
man |
LD50 |
oral |
30mg/kg (30mg/kg) |
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: COMA |
Handbook of Experimental Pharmacology. Vol. 55, Pg. 527, 1980. |
man |
LDLo |
oral |
71mg/kg (71mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
CARDIAC: CHANGE IN RATE
ENDOCRINE: CHANGE IN LH |
Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 239, 1982. |
man |
TDLo |
oral |
5357ug/kg/5D- (5.357mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: CHANGE IN REM SLEEP (HUMAN) |
Human Psychopharmacology. Vol. 11, Pg. 211, 1996. |
man |
TDLo |
oral |
8mg/kg/3D-I (8mg/kg) |
BEHAVIORAL: EXCITEMENT |
Lancet. Vol. 2, Pg. 568, 1959. |
man |
TDLo |
oral |
71428ug/kg/10 (71.428mg/kg) |
BEHAVIORAL: REGIDITY
SKIN AND APPENDAGES (SKIN): SWEATING: OTHER |
Intensive Care Medicine. Vol. 23, Pg. 480, 1997. |
mouse |
LD50 |
intraperitoneal |
51600ug/kg (51.6mg/kg) |
|
British Patent Document. Vol. #1460700, |
mouse |
LD50 |
intravenous |
21mg/kg (21mg/kg) |
AUTONOMIC NERVOUS SYSTEM: PARASYMPATHOLYTIC
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: WAKEFULNESS |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 245, Pg. 283, 1980. |
mouse |
LD50 |
oral |
188mg/kg (188mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Pharmaceutical Chemistry Journal Vol. 14, Pg. 773, 1980. |
mouse |
LD50 |
subcutaneous |
195ug/kg (0.195mg/kg) |
BEHAVIORAL: WAKEFULNESS |
Pharmaceutical Chemistry Journal Vol. 15, Pg. 412, 1981. |
mouse |
LD50 |
unreported |
107mg/kg (107mg/kg) |
AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" |
Journal of Medicinal Chemistry. Vol. 10, Pg. 418, 1967. |
rabbit |
LD50 |
intravenous |
18mg/kg (18mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959. |
rabbit |
LD50 |
oral |
385mg/kg (385mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1617, 1969. |
rat |
LD50 |
intraperitoneal |
79mg/kg (79mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964. |
rat |
LD50 |
intravenous |
9300ug/kg (9.3mg/kg) |
|
United States Patent Document. Vol. #4141993, |
rat |
LD50 |
oral |
250mg/kg (250mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Pharmaceutical Chemistry Journal Vol. 14, Pg. 773, 1980. |
rat |
LD50 |
subcutaneous |
250mg/kg (250mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964. |
women |
LDLo |
oral |
2mg/kg/1D (2mg/kg) |
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 265, 1964. |
women |
TDLo |
oral |
3mg/kg/32H-I (3mg/kg) |
SKIN AND APPENDAGES (SKIN): PHOTOSENSITIVITY: AFTER SYSTEMIC EXPOSURE |
JAMA, Journal of the American Medical Association. Vol. 254, Pg. 357, 1985. |
women |
TDLo |
oral |
150mg/kg (150mg/kg) |
BEHAVIORAL: COMA
CARDIAC: OTHER CHANGES
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION |
Journal of Toxicology, Clinical Toxicology. Vol. 33, Pg. 51, 1995. |