| cat |
LD50 |
subcutaneous |
> 10mg/kg (10mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
|
| cat |
LDLo |
oral |
100mg/kg (100mg/kg) |
behavioral: altered sleep time (including change in righting reflex)
behavioral: regidity
gastrointestinal: nausea or vomiting
|
Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976. |
| child |
LDLo |
oral |
37500ug/kg (37.5mg/kg) |
behavioral: convulsions or effect on seizure threshold
behavioral: coma
|
New England Journal of Medicine. Vol. 256, Pg. 527, 1957. |
| dog |
LD50 |
intravenous |
30mg/kg (30mg/kg) |
ungs, thorax, or respiration: emphysema
blood: hemorrhage
lungs, thorax, or respiration: acute pulmona |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
|
| dog |
LD50 |
subcutaneous |
> 20mg/kg (20mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
|
| dog |
LDLo |
oral |
250mg/kg (250mg/kg) |
behavioral: altered sleep time (including change in righting reflex)
behavioral: regidity
gastrointestinal: nausea or vomiting |
Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976. |
| guinea pig |
LD50 |
intraperitoneal |
87mg/kg (87mg/kg) |
|
Medicina Experimentalis. Vol. 8, Pg. 237, 1963. |
| guinea pig |
LDLo |
oral |
250mg/kg (250mg/kg) |
behavioral: altered sleep time (including change in righting reflex)
behavioral: regidity
gastrointestinal: nausea or vomiting
|
Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976. |
| human |
TDLo |
oral |
8570ug/kg/12D (8.57mg/kg) |
behavioral: wakefulness
behavioral: muscle weakness
behavioral: tremor
|
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 93, 1972.
|
| infant |
TDLo |
oral |
20mg/kg (20mg/kg) |
vascular: bp lowering not characterized in autonomic section
behavioral: somnolence (general depressed activity)
|
American Journal of Diseases of Children. Vol. 130, Pg. 507, 1976.
|
| mammal (species unspecified) |
LD50 |
oral |
500mg/kg (500mg/kg) |
behavioral: anticonvulsant
behavioral: alteration of classical conditioning
|
Journal of Medicinal Chemistry. Vol. 8, Pg. 836, 1965. |
| man |
TDLo |
oral |
8900ug/kg (8.9mg/kg) |
lungs, thorax, or respiration: dyspnea
|
American Journal of Emergency Medicine. Vol. 14, Pg. 467, 1996.
|
| man |
TDLo |
oral |
217mg/kg/19D (217mg/kg) |
blood: agranulocytosis
skin and appendages (skin): "dermatitis, allergic: after systemic exposure"
|
Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
|
| monkey |
LD50 |
subcutaneous |
> 5mg/kg (5mg/kg) |
blood: agranulocytosis
skin and appendages (skin): "dermatitis, allergic: after systemic exposure"
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
|
| mouse |
LC50 |
inhalation |
209mg/m3/2H (209mg/m3) |
behavioral: muscle weakness
cardiac: pulse rate increase without fall in bp
blood: leukopenia
|
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 73, 1968. |
| mouse |
LD50 |
intraperitoneal |
14mg/kg (14mg/kg) |
|
Farmaco, Edizione Scientifica. Vol. 14, Pg. 269, 1959. |
| mouse |
LD50 |
intravenous |
16mg/kg (16mg/kg) |
behavioral: muscle weakness
cardiac: pulse rate increase without fall in bp
blood: leukopenia
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
|
| mouse |
LD50 |
oral |
135mg/kg (135mg/kg) |
lbehavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: other changes
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
|
| mouse |
LD50 |
subcutaneous |
33mg/kg (33mg/kg) |
behavioral: ataxia
behavioral: regidity
|
Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
|
| mouse |
LD50 |
unreported |
82500ug/kg (82.5mg/kg) |
|
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 2S, 1957. |
| mouse |
LDLo |
intramuscular |
300mg/kg (300mg/kg) |
|
Therapie. Vol. 15, Pg. 1064, 1960. |
| rabbit |
LD50 |
intravenous |
16mg/kg (16mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
|
| rat |
LC50 |
inhalation |
209mg/m3/2H (209mg/m3) |
behavioral: muscle weakness
cardiac: pulse rate increase without fall in bp
blood: leukopenia
|
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 73, 1968. |
| rat |
LD50 |
intraperitoneal |
137mg/kg (137mg/kg) |
|
German Offenlegungsschrift Patent Document. Vol. #2350222, |
| rat |
LD50 |
intravenous |
23mg/kg (23mg/kg) |
behavioral: muscle weakness
cardiac: pulse rate increase without fall in bp
blood: leukopenia
|
Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
|
| rat |
LD50 |
oral |
142mg/kg (142mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
|
| rat |
LD50 |
subcutaneous |
75mg/kg (75mg/kg) |
|
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 377, 1960. |
| women |
TDLo |
oral |
200ug/kg (0.2mg/kg) |
behavioral: sleep
liver: "jaundice, other or unclassified" |
New York State Journal of Medicine. Vol. 57, Pg. 1922, 1957.
|
| women |
TDLo |
oral |
16800ug/kg/3W (16.8mg/kg) |
blood: agranulocytosis |
Postgraduate Medical Journal. Vol. 69, Pg. 885, 1993.
|
| women |
TDLo |
oral |
166mg/kg/18D- (166mg/kg) |
blood: other hemolysis with or without anemia
blood: other changes |
Postgraduate Medical Journal. Vol. 53, Pg. 278, 1977.
|
| women |
TDLo |
oral |
240mg/kg/30D- (240mg/kg) |
blood: agranulocytosis
blood: changes in leucocyte (wbc) count
blood: agranulocytosis |
Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
|
| women |
TDLo |
oral |
240mg/kg/30D (240mg/kg) |
skin and appendages (skin): "dermatitis, allergic: after systemic exposure"
|
Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
|
