50-53-3|10H-Phenothiazine-10-propanamine,2-chloro-N,N-dimethyl-Products Supply

10H-Phenothiazine-10-propanamine,2-chloro-N,N-dimethyl- cas no:50-53-3

Synonyms: Phenothiazine,2-chloro-10-[3-(dimethylamino)propyl]- (7CI,8CI);2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine; 2-Chloropromazine; 2601A;Aminazin; Aminazine; Ampliactil; Amplictil; BC 135; CPZ; Chlor-Promanyl;Chlordelazin; Chlorderazin; Chlorpromados; Chlorpromazine; Chlropromados;Contomin; Elmarin; Esmind; Fenactil; Fenaktyl; Fraction AB; HL 5746;Largactilothiazine; Largactyl; Megaphen; NSC 167745; NSC 226514; Noiafren;Novomazina; Phenactyl; Proma; Promactil; Promazil; Propaphenin; Prozil; RP4560; SKF 2601A; Sanopron; Sedatil; Thorazin; Thorazine; Wintermin

Identification

Name10H-Phenothiazine-10-propanamine,2-chloro-N,N-dimethyl-
CAS50-53-3
SynonymsPhenothiazine,2-chloro-10-[3-(dimethylamino)propyl]- (7CI,8CI);2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine; 2-Chloropromazine; 2601A;Aminazin; Aminazine; Ampliactil; Amplictil; BC 135; CPZ; Chlor-Promanyl;Chlordelazin; Chlorderazin; Chlorpromados; Chlorpromazine; Chlropromados;Contomin; Elmarin; Esmind; Fenactil; Fenaktyl; Fraction AB; HL 5746;Largactilothiazine; Largactyl; Megaphen; NSC 167745; NSC 226514; Noiafren;Novomazina; Phenactyl; Proma; Promactil; Promazil; Propaphenin; Prozil; RP4560; SKF 2601A; Sanopron; Sedatil; Thorazin; Thorazine; Wintermin
EINECS(EC#)200-045-8
Molecular FormulaC17H19 Cl N2 S
Molecular Weight318.86

Chemical Properties

Appearancewhite to off-white crystalline powder

Safety Data

Hazard 6.1 (Packing Group: III) UN NO.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	subcutaneous	> 10mg/kg (10mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
cat	LDLo	oral	100mg/kg (100mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
child	LDLo	oral	37500ug/kg (37.5mg/kg)	behavioral: convulsions or effect on seizure threshold behavioral: coma	New England Journal of Medicine. Vol. 256, Pg. 527, 1957.
dog	LD50	intravenous	30mg/kg (30mg/kg)	ungs, thorax, or respiration: emphysema blood: hemorrhage lungs, thorax, or respiration: acute pulmona	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
dog	LD50	subcutaneous	> 20mg/kg (20mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
dog	LDLo	oral	250mg/kg (250mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
guinea pig	LD50	intraperitoneal	87mg/kg (87mg/kg)		Medicina Experimentalis. Vol. 8, Pg. 237, 1963.
guinea pig	LDLo	oral	250mg/kg (250mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: regidity gastrointestinal: nausea or vomiting	Oyo Yakuri. Pharmacometrics. Vol. 11, Pg. 561, 1976.
human	TDLo	oral	8570ug/kg/12D (8.57mg/kg)	behavioral: wakefulness behavioral: muscle weakness behavioral: tremor	Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 93, 1972.
infant	TDLo	oral	20mg/kg (20mg/kg)	vascular: bp lowering not characterized in autonomic section behavioral: somnolence (general depressed activity)	American Journal of Diseases of Children. Vol. 130, Pg. 507, 1976.
mammal (species unspecified)	LD50	oral	500mg/kg (500mg/kg)	behavioral: anticonvulsant behavioral: alteration of classical conditioning	Journal of Medicinal Chemistry. Vol. 8, Pg. 836, 1965.
man	TDLo	oral	8900ug/kg (8.9mg/kg)	lungs, thorax, or respiration: dyspnea	American Journal of Emergency Medicine. Vol. 14, Pg. 467, 1996.
man	TDLo	oral	217mg/kg/19D (217mg/kg)	blood: agranulocytosis skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
monkey	LD50	subcutaneous	> 5mg/kg (5mg/kg)	blood: agranulocytosis skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LC50	inhalation	209mg/m3/2H (209mg/m3)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 73, 1968.
mouse	LD50	intraperitoneal	14mg/kg (14mg/kg)		Farmaco, Edizione Scientifica. Vol. 14, Pg. 269, 1959.
mouse	LD50	intravenous	16mg/kg (16mg/kg)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	oral	135mg/kg (135mg/kg)	lbehavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: other changes	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 118, Pg. 358, 1959.
mouse	LD50	subcutaneous	33mg/kg (33mg/kg)	behavioral: ataxia behavioral: regidity	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 932, 1961.
mouse	LD50	unreported	82500ug/kg (82.5mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 53, Pg. 2S, 1957.
mouse	LDLo	intramuscular	300mg/kg (300mg/kg)		Therapie. Vol. 15, Pg. 1064, 1960.
rabbit	LD50	intravenous	16mg/kg (16mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 120, Pg. 450, 1959.
rat	LC50	inhalation	209mg/m3/2H (209mg/m3)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 73, 1968.
rat	LD50	intraperitoneal	137mg/kg (137mg/kg)		German Offenlegungsschrift Patent Document. Vol. #2350222,
rat	LD50	intravenous	23mg/kg (23mg/kg)	behavioral: muscle weakness cardiac: pulse rate increase without fall in bp blood: leukopenia	Farmaco, Edizione Pratica. Vol. 26, Pg. 585, 1971.
rat	LD50	oral	142mg/kg (142mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
rat	LD50	subcutaneous	75mg/kg (75mg/kg)		Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 56, Pg. 377, 1960.
women	TDLo	oral	200ug/kg (0.2mg/kg)	behavioral: sleep liver: "jaundice, other or unclassified"	New York State Journal of Medicine. Vol. 57, Pg. 1922, 1957.
women	TDLo	oral	16800ug/kg/3W (16.8mg/kg)	blood: agranulocytosis	Postgraduate Medical Journal. Vol. 69, Pg. 885, 1993.
women	TDLo	oral	166mg/kg/18D- (166mg/kg)	blood: other hemolysis with or without anemia blood: other changes	Postgraduate Medical Journal. Vol. 53, Pg. 278, 1977.
women	TDLo	oral	240mg/kg/30D- (240mg/kg)	blood: agranulocytosis blood: changes in leucocyte (wbc) count blood: agranulocytosis	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.
women	TDLo	oral	240mg/kg/30D (240mg/kg)	skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	Journal of Clinical Psychiatry. Vol. 46, Pg. 341, 1985.

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10H-Phenothiazine-10-propanamine,2-chloro-N,N-dimethyl- cas no:50-53-3

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