| child |
LDLo |
oral |
104mg/kg (104mg/kg) |
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: HEMORRHAGE |
Lancet. Vol. 2, Pg. 809, 1952. |
| child |
TDLo |
oral |
10mg/kg/1D-I (10mg/kg) |
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED |
Clinical Toxicology. Vol. 18, Pg. 247, 1981. |
| child |
TDLo |
oral |
39mg/kg/13D-I (39mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" |
American Journal of Diseases of Children. Vol. 139, Pg. 453, 1985. |
| dog |
LD50 |
intravenous |
681mg/kg (681mg/kg) |
BEHAVIORAL: ANALGESIA |
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. |
| dog |
LD50 |
oral |
700mg/kg (700mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION |
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971. |
| guinea pig |
LD50 |
oral |
1075mg/kg (1075mg/kg) |
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: TREMOR
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) |
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. |
| hamster |
LD50 |
oral |
3500mg/kg (3500mg/kg) |
? |
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. |
| human |
TDLo |
oral |
480mg/kg/7D-I (480mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: OTHER CHANGES |
Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 281, 1975. |
| human |
TDLo |
oral |
669mg/kg/11D (669mg/kg) |
LIVER: LIVER FUNCTION TESTS IMPAIRED |
American Journal of Hospital Pharmacy. Vol. 35, Pg. 330, 1978. |
| human |
TDLo |
oral |
1050mg/kg/14D (1050mg/kg) |
VASCULAR: OTHER CHANGES |
Clinical Pharmacology and Therapeutics Vol. 67, Pg. 530, 2000. |
| human |
TDLo |
oral |
2880mg/kg/8W (2880mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR
GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION |
Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 631, 1983. |
| infant |
TDLo |
oral |
120mg/kg (120mg/kg) |
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
KIDNEY, URETER, AND BLADDER: HEMATURIA |
British Medical Journal. Vol. 1, Pg. 1081, 1979. |
| mammal (species unspecified) |
LD50 |
oral |
1750mg/kg (1750mg/kg) |
? |
Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985. |
| man |
LDLo |
unreported |
294mg/kg (294mg/kg) |
? |
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. |
| man |
TDLo |
oral |
857mg/kg (857mg/kg) |
BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Human Toxicology. Vol. 7, Pg. 161, 1988. |
| man |
TDLo |
oral |
1625mg/kg (1625mg/kg) |
BEHAVIORAL: COMA |
Clinical Pediatrics Vol. 24, Pg. 678, 1985. |
| man |
TDLo |
oral |
13036mg/kg/5Y (13036mg/kg) |
GASTROINTESTINAL: OTHER CHANGES
MUSCULOSKELETAL: JOINTS
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Annals of Internal Medicine. Vol. 126, Pg. 665, 1997. |
| mouse |
LD50 |
intraperitoneal |
167mg/kg (167mg/kg) |
? |
United States Patent Document. Vol. #4376771, |
| mouse |
LD50 |
oral |
250mg/kg (250mg/kg) |
? |
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. |
| mouse |
LD50 |
subcutaneous |
1020mg/kg (1020mg/kg) |
? |
Chemical and Pharmaceutical Bulletin. Vol. 28, Pg. 1237, 1980. |
| mouse |
LD50 |
unreported |
1350mg/kg (1350mg/kg) |
? |
United States Patent Document. Vol. #5240918, |
| rabbit |
LD50 |
oral |
1010mg/kg (1010mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) |
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 43, 1980. |
| rat |
LD50 |
intraperitoneal |
340mg/kg (340mg/kg) |
? |
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62, Pg. 11, 1966. |
| rat |
LD50 |
oral |
200mg/kg (200mg/kg) |
? |
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969. |
| rat |
LD50 |
rectal |
790mg/kg (790mg/kg) |
? |
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969. |
| women |
TDLo |
oral |
480mg/kg/5D-I (480mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" |
New England Journal of Medicine. Vol. 296, Pg. 418, 1977. |
| women |
TDLo |
oral |
525mg/kg/5D-I (525mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" |
Annals of Internal Medicine. Vol. 80, Pg. 74, 1974. |
| women |
TDLo |
oral |
800mg/kg (800mg/kg) |
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
MUSCULOSKELETAL: OTHER CHANGES |
American Journal of Emergency Medicine. Vol. 7, Pg. 409, 1989. |
| women |
TDLo |
rectal |
4550mg/kg (4550mg/kg) |
BRAIN AND COVERINGS: ENCEPHALITIS
BEHAVIORAL: COMA
CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) |
Annals of Pharmacotherpy. Vol. 28, Pg. 467, 1994. |
