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Floxuridine cas no:50-91-9

Synonyms: 1-(2-Deoxy-b-D-ribofuranosyl)-5-fluorouracil;5-Fluoro-2'-deoxy-b-uridine;5-Fluoro-2'-deoxyuridine;5-Fluorodeoxyuridine;5-Fluorouracil 2'-deoxyriboside;5-Fluorouracil deoxyriboside;Floxuridin;NSC 26740;NSC 27640;2'-Deoxy-5-fluorouridine;

Identification
NameFloxuridine
CAS50-91-9
Synonyms1-(2-Deoxy-b-D-ribofuranosyl)-5-fluorouracil;5-Fluoro-2'-deoxy-b-uridine;5-Fluoro-2'-deoxyuridine;5-Fluorodeoxyuridine;5-Fluorouracil 2'-deoxyriboside;5-Fluorouracil deoxyriboside;Floxuridin;NSC 26740;NSC 27640;2'-Deoxy-5-fluorouridine;
EINECS(EC#)200-072-5
Molecular FormulaC9H11FN2O5
Molecular Weight246.19
Chemical Properties
Appearancewhite to off-white crystalline powder
alpha35.9 o (C=1, WATER)
refractive index1.608
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard Xn:Harmful
Risk R22;R36/37/38;R68
Safety

Hazard Codes 2'-Deoxy-5-fluorouridine (CAS NO.50-91-9):?Xn,T,Xi
Risk Statements: 68-36/37/38-40-20/21/22?
R68: Possible risk of irreversible effects.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R40: Limited evidence of a carcinogenic effect.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36/37/39-26?
S22: Do not breathe dust.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YU7525000
F: 10-23
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
Poison by ingestion. Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Human systemic effects: hypermotility, diarrhea, nausea, vomiting and other gastrointestinal effects, allergic dermatitis, and bone marrow changes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F? and NOx?.?


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intravenous 5mg/kg/14D-C (5mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES
Cancer Vol. 34, Pg. 972, 1974.
mouse LD50 intraperitoneal 650mg/kg (650mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING
Proceedings of the Society for Experimental Biology and Medicine. Vol. 97, Pg. 470, 1958.
mouse LD50 oral 147mg/kg (147mg/kg) ? Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
mouse LD50 unreported 550mg/kg (550mg/kg) ? Cancer Research. Vol. 46, Pg. 2703, 1986.
rat LD50 intraperitoneal 1600mg/kg (1600mg/kg) ? Clinical Proceedings of the Children's Hospital of the District of Columbia. Vol. 18, Pg. 307, 1962.
rat LD50 oral 215mg/kg (215mg/kg) ? Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
women TDLo parenteral 173mg/kg/82W- (173mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" Journal of the National Medical Association. Vol. 79, Pg. 669, 1987.

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