50-91-9|FloxuridineProducts Supply - Chemical intermediates Network

Floxuridine cas no:50-91-9

Synonyms: 1-(2-Deoxy-b-D-ribofuranosyl)-5-fluorouracil;5-Fluoro-2'-deoxy-b-uridine;5-Fluoro-2'-deoxyuridine;5-Fluorodeoxyuridine;5-Fluorouracil 2'-deoxyriboside;5-Fluorouracil deoxyriboside;Floxuridin;NSC 26740;NSC 27640;2'-Deoxy-5-fluorouridine;

Identification

NameFloxuridine
CAS50-91-9
Synonyms1-(2-Deoxy-b-D-ribofuranosyl)-5-fluorouracil;5-Fluoro-2'-deoxy-b-uridine;5-Fluoro-2'-deoxyuridine;5-Fluorodeoxyuridine;5-Fluorouracil 2'-deoxyriboside;5-Fluorouracil deoxyriboside;Floxuridin;NSC 26740;NSC 27640;2'-Deoxy-5-fluorouridine;
EINECS(EC#)200-072-5
Molecular FormulaC₉H₁₁FN₂O₅
Molecular Weight246.19

Chemical Properties

Appearancewhite to off-white crystalline powder
alpha35.9 o (C=1, WATER)
refractive index1.608
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1

Safety Data

Hazard Xn:Harmful
Risk R22;R36/37/38;R68
Safety

Hazard Codes 2'-Deoxy-5-fluorouridine (CAS NO.50-91-9):?Xn,T,Xi
Risk Statements: 68-36/37/38-40-20/21/22?
R68: Possible risk of irreversible effects.?
R36/37/38: Irritating to eyes, respiratory system and skin.?
R40: Limited evidence of a carcinogenic effect.?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 22-36/37/39-26?
S22: Do not breathe dust.?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YU7525000
F: 10-23
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
Poison by ingestion. Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Human systemic effects: hypermotility, diarrhea, nausea, vomiting and other gastrointestinal effects, allergic dermatitis, and bone marrow changes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F^? and NO_x?.?

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	intravenous	5mg/kg/14D-C (5mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: OTHER CHANGES	Cancer Vol. 34, Pg. 972, 1974.
mouse	LD50	intraperitoneal	650mg/kg (650mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	Proceedings of the Society for Experimental Biology and Medicine. Vol. 97, Pg. 470, 1958.
mouse	LD50	oral	147mg/kg (147mg/kg)	?	Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
mouse	LD50	unreported	550mg/kg (550mg/kg)	?	Cancer Research. Vol. 46, Pg. 2703, 1986.
rat	LD50	intraperitoneal	1600mg/kg (1600mg/kg)	?	Clinical Proceedings of the Children's Hospital of the District of Columbia. Vol. 18, Pg. 307, 1962.
rat	LD50	oral	215mg/kg (215mg/kg)	?	Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
women	TDLo	parenteral	173mg/kg/82W- (173mg/kg)	SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"	Journal of the National Medical Association. Vol. 79, Pg. 669, 1987.

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Angene International Limited: Tel:852-852-81916999; Address: 4/F Silvercord Center Tower 1, 30 Canton Rd,KL,Hong Kong

Floxuridine cas no:50-91-9

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