Phosphorothioic acid,O-(3-chloro-4-nitrophenyl) O,O-dimethyl ester cas no:500-28-7

NamePhosphorothioic acid,O-(3-chloro-4-nitrophenyl) O,O-dimethyl ester
CAS500-28-7
SynonymsPhosphorothioicacid, O-(3-chloro-4-nitrophenyl) O,O-di-Me ester (6CI); BAY 22190; Chlorothion;Chlorthion; Chlorthion methyl; Compound 22/190; Methylchlorothion; NSC 8927;O,O-Dimethyl O-(3-chloro-4-nitrophenyl) thiophosphate; O,O-DimethylO-(3-chloro-4-nitrophenyl)thionophosphate; O,O-DimethylO-3-chloro-4-nitrophenyl phosphorothioate; O-(3-Chloro-4-nitrophenyl)O,O-dimethyl phosphorothioate; OMS 217
EINECS(EC#)207-902-5
Molecular FormulaC8H9 Cl N O5 P S
Molecular Weight297.66

refractive index1.586
storage temp2-8°C

Hazard Xn,N
Risk 20/21/22-50/53
Safety

The Hazard Codes of Chlorthion (CAS NO.500-28-7): XnN
Risk Statements:R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. R50/53:Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements:S13:Keep away from food, drink and animal foodstuffs. S60:This material and its container must be disposed of as hazardous waste. S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
Moderately toxic by ingestion, skin contact, and intraperitoneal routes. An insecticide. Decomposes and then ignites when heated above 270°C. When heated to decomposition it emits very toxic fumes of Cl⁻, SO_x, PO_x, and NO_x.

The toxicity of Chlorthion (CAS NO.500-28-7):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
bird - wild	LD50	oral	20mg/kg (20mg/kg)		Journal de Toxicologie Clinique et Experimentale. Vol. 6(3), Pg. 175, 1986.
guinea pig	LD50	intraperitoneal	525mg/kg (525mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 626, 1955.
guinea pig	LD50	subcutaneous	25mg/kg (25mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
mouse	LD50	oral	794mg/kg (794mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Archives of Toxicology. Vol. 41, Pg. 111, 1978.
rabbit	LD50	subcutaneous	25mg/kg (25mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
rabbit	LDLo	oral	1gm/kg (1000mg/kg)		Journal of Economic Entomology. Vol. 48, Pg. 139, 1955.
rat	LD50	intraperitoneal	750mg/kg (750mg/kg)		AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 350, 1953.
rat	LD50	intraperitoneal	750mg/kg (750mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 350, 1953.
rat	LD50	oral	285mg/kg (285mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
rat	LD50	skin	1500mg/kg (1500mg/kg)		World Review of Pest Control. Vol. 9, Pg. 119, 1970.
rat	LD50	subcutaneous	47mg/kg (47mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 7, Pg. 122, 1965.
rat	LD50	unreported	880mg/kg (880mg/kg)		"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971Vol. -, Pg. 331, 1971.