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Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)- cas no:500-92-5

Synonyms: Biguanide,1-(p-chlorophenyl)-5-isopropyl- (8CI); 1-(p-Chlorophenyl)-5-isopropylbiguanide;1-Isopropyl-5-(4-chlorophenyl)biguanide; Bigumal; Chlorguanid; Chlorguanide;Chloroguanide; N1-p-Chlorophenyl-N5-isopropylbiguanide; Paludrin; Proguanil

Identification
NameImidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
CAS500-92-5
SynonymsBiguanide,1-(p-chlorophenyl)-5-isopropyl- (8CI); 1-(p-Chlorophenyl)-5-isopropylbiguanide;1-Isopropyl-5-(4-chlorophenyl)biguanide; Bigumal; Chlorguanid; Chlorguanide;Chloroguanide; N1-p-Chlorophenyl-N5-isopropylbiguanide; Paludrin; Proguanil
EINECS(EC#)207-915-6
Molecular FormulaC11H16 Cl N5
Molecular Weight253.77
Safety Data

Safety

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl and NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intravenous 60mg/kg (60mg/kg)   Compilation of LD50 Values of New Drugs.
chicken LDLo oral 400mg/kg (400mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 intravenous 22mg/kg (22mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 4, Pg. 14, 1949.
mouse LDLo intraperitoneal 25mg/kg (25mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LDLo oral 50mg/kg (50mg/kg)   Compilation of LD50 Values of New Drugs.
rabbit LD50 intraperitoneal 50mg/kg (50mg/kg)   Compilation of LD50 Values of New Drugs.
rabbit LD50 oral 150mg/kg (150mg/kg)   Compilation of LD50 Values of New Drugs.
rat LD50 intraperitoneal 15mg/kg (15mg/kg)   "International Congress of Chemotherapy, Proceedings of the 3rd Congress, 1963," Kuemmerle, H.P., and Prezios, P., Stuttgart, Fed. Rep. Ger., Georg Thieme Verlag, 1964Vol. -, Pg. 367, 1964.
rat LDLo intravenous 40mg/kg (40mg/kg)   Compilation of LD50 Values of New Drugs.

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