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Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)- cas no:500-92-5

Synonyms: Biguanide,1-(p-chlorophenyl)-5-isopropyl- (8CI); 1-(p-Chlorophenyl)-5-isopropylbiguanide;1-Isopropyl-5-(4-chlorophenyl)biguanide; Bigumal; Chlorguanid; Chlorguanide;Chloroguanide; N1-p-Chlorophenyl-N5-isopropylbiguanide; Paludrin; Proguanil

Identification
NameImidodicarbonimidicdiamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-
CAS500-92-5
SynonymsBiguanide,1-(p-chlorophenyl)-5-isopropyl- (8CI); 1-(p-Chlorophenyl)-5-isopropylbiguanide;1-Isopropyl-5-(4-chlorophenyl)biguanide; Bigumal; Chlorguanid; Chlorguanide;Chloroguanide; N1-p-Chlorophenyl-N5-isopropylbiguanide; Paludrin; Proguanil
EINECS(EC#)207-915-6
Molecular FormulaC11H16 Cl N5
Molecular Weight253.77
Safety Data

Safety

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl− and NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intravenous 60mg/kg (60mg/kg)   Compilation of LD50 Values of New Drugs.
chicken LDLo oral 400mg/kg (400mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LD50 intravenous 22mg/kg (22mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 4, Pg. 14, 1949.
mouse LDLo intraperitoneal 25mg/kg (25mg/kg)   Compilation of LD50 Values of New Drugs.
mouse LDLo oral 50mg/kg (50mg/kg)   Compilation of LD50 Values of New Drugs.
rabbit LD50 intraperitoneal 50mg/kg (50mg/kg)   Compilation of LD50 Values of New Drugs.
rabbit LD50 oral 150mg/kg (150mg/kg)   Compilation of LD50 Values of New Drugs.
rat LD50 intraperitoneal 15mg/kg (15mg/kg)   "International Congress of Chemotherapy, Proceedings of the 3rd Congress, 1963," Kuemmerle, H.P., and Prezios, P., Stuttgart, Fed. Rep. Ger., Georg Thieme Verlag, 1964Vol. -, Pg. 367, 1964.
rat LDLo intravenous 40mg/kg (40mg/kg)   Compilation of LD50 Values of New Drugs.

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Boc Sciences
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