|
child
|
TDLo
|
oral
|
3mg/kg (3mg/kg)
|
skin and appendages (skin): "dermatitis, other: after systemic exposure"
|
British Medical Journal. Vol. 293, Pg. 536, 1986.
|
|
dog
|
LD
|
oral
|
> 1500mg/kg (1500mg/kg)
|
gastrointestinal: nausea or vomiting
|
Oyo Yakuri. Pharmacometrics. Vol. 31, Pg. 845, 1986.
|
|
guinea pig
|
LD50
|
oral
|
> 2gm/kg (2000mg/kg)
|
|
Merck Index. Vol. 11, Pg. 1443, 1989.
|
|
human
|
TDLo
|
oral
|
857ug/kg (0.857mg/kg)
|
behavioral: somnolence (general depressed activity)
behavioral: alteration of operant conditioning
behavioral: changes in psychophysiological tests
|
European Journal of Clinical Pharmacology. Vol. 47, Pg. 331, 1994.
|
|
mammal (species unspecified)
|
LD50
|
intraperitoneal
|
43mg/kg (43mg/kg)
|
|
Journal of Medicinal Chemistry. Vol. 38, Pg. 2472, 1995.
|
|
man
|
TDLo
|
oral
|
857ug/kg (0.857mg/kg)
|
skin and appendages (skin): "dermatitis, other: after systemic exposure"
|
British Medical Journal. Vol. 293, Pg. 536, 1986.
|
|
man
|
TDLo
|
oral
|
36mg/kg/3W-I (36mg/kg)
|
liver: "jaundice, cholestatic"
liver: liver function tests impaired
|
Lancet. Vol. 348, Pg. 552, 1996.
|
|
man
|
TDLo
|
oral
|
156mg/kg/13W- (156mg/kg)
|
skin and appendages (skin): hair: other
|
British Medical Journal. Vol. 291, Pg. 940, 1985.
|
|
mouse
|
LD50
|
intraperitoneal
|
100mg/kg (100mg/kg)
|
|
United States Patent Document. Vol. #4908365,
|
|
mouse
|
LD50
|
oral
|
5gm/kg (5000mg/kg)
|
|
Pharmacy International. Vol. 4, Pg. 252, 1983.
|
|
mouse
|
LD50
|
subcutaneous
|
> 4500mg/kg (4500mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 707, 1990.
|
|
rat
|
LD50
|
intraperitoneal
|
154mg/kg (154mg/kg)
|
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
|
|
rat
|
LD50
|
oral
|
5gm/kg (5000mg/kg)
|
|
Pharmacy International. Vol. 4, Pg. 252, 1983.
|
|
rat
|
LD50
|
subcutaneous
|
> 1250mg/kg (1250mg/kg)
|
|
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 21, Pg. 319, 1990.
|
|
women
|
TDLo
|
oral
|
1200ug/kg (1.2mg/kg)
|
skin and appendages (skin): "dermatitis, other: after systemic exposure"
|
British Medical Journal. Vol. 293, Pg. 536, 1986.
|
|
women
|
TDLo
|
oral
|
190mg/kg/23W- (190mg/kg)
|
behavioral: muscle weakness
liver: "jaundice, other or unclassified"
liver: liver function tests impaired
|
Annals of Internal Medicine. Vol. 103, Pg. 634, 1985.
|
