Card-20(22)-enolide,3-[(2,6-dideoxy-3-O-methyl-b-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3b,5b)- cas no:508-77-0

NameCard-20(22)-enolide,3-[(2,6-dideoxy-3-O-methyl-b-D-ribo-hexopyranosyl)oxy]-5,14-dihydroxy-19-oxo-, (3b,5b)-
CAS508-77-0
SynonymsCymarin(6CI,7CI,8CI);Alvonal MR;Cymarine;K-Strophanthin-a;NSC 7522;Strophantin K;WV 90043a;
EINECS(EC#)208-087-9
Molecular FormulaC30H44 O9
Molecular Weight548.74

refractive index1.589
storage temp2-8°C

Hazardclass6.1(b)

Hazard T: Toxic;
Risk R23/25
Safety

Poison by intravenous, intraperitoneal, and possibly other routes. Used as a cardiotonic. When heated to decomposition it emits acrid smoke and fumes.
Safety Information of Cymarin (CAS NO.508-77-0):
Hazard Codes: T,T+
Risk Statements: 23/25-33-26/27/28 
23:  Toxic by inhalation 
25:  Toxic if swallowed 
26:  Very Toxic by inhalation 
27:  Very Toxic in contact with skin 
28:  Very Toxic if swallowed 
33:  Danger of cumulative effects 
Safety Statements: 45-36/37/39
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 
39:  Wear eye/face protection 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intravenous	95ug/kg (0.095mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 223, 1942.
cat	LD50	parenteral	110ug/kg (0.11mg/kg)		Bollettino Chimico Farmaceutico. Vol. 98, Pg. 297, 1959.
cat	LDLo	unreported	110ug/kg (0.11mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964.
mouse	LD50	intracrebral	41ug/kg (0.041mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 908, 1961.
mouse	LD50	intraperitoneal	12mg/kg (12mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965.
mouse	LD50	intravenous	2800ug/kg (2.8mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 908, 1961.
rat	LD50	intravenous	20mg/kg (20mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965.