50847-11-5|IbudilastProducts Supply - Chemical intermediates Network

Ibudilast cas no:50847-11-5

Synonyms: Pyrazolo[1,5-a]pyridine,1-propanone deriv.;1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one;2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine;AV 411;KC 404;Ketas;1-Propanone,2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-;

Identification

NameIbudilast
CAS50847-11-5
SynonymsPyrazolo[1,5-a]pyridine,1-propanone deriv.;1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methylpropan-1-one;2-Isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine;AV 411;KC 404;Ketas;1-Propanone,2-methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-;
Molecular FormulaC₁₄H₁₈N₂O
Molecular Weight230.30552

Chemical Properties

Appearancewhite solid
refractive index1.57
storage temp2-8°C

Safety Data

Hazard Xn:Harmful;
Risk R22;R36/37/38
Safety

Safety Information about?Ibudilast (CAS NO.50847-11-5):
Hazard Codes:? Harmful Xn
Risk Statements: 22-36/37/38
R22: Harmful if swallowed.?
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: UR0711200

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	460mg/kg (460mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	intravenous	146mg/kg (146mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	oral	1860mg/kg (1860mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
mouse	LD50	subcutaneous	3100mg/kg (3100mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	intraperitoneal	419mg/kg (419mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	intravenous	42500ug/kg (42.5mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE KIDNEY, URETER, AND BLADDER: HEMATURIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	oral	1340mg/kg (1340mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.
rat	LD50	subcutaneous	1300mg/kg (1300mg/kg)	KIDNEY, URETER, AND BLADDER: HEMATURIA	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5503, 1985.

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Ibudilast cas no:50847-11-5

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