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Fluorouracil (5-Fluorouracil) cas no:51-21-8

Synonyms: Ro-2-9757;Phtoruracil;Ulup;2,4(1H,3H)-Pyrimidinedione,5-fluoro-;Phthoruracil;Uracil, 5-fluoro-;5-Fluoro-2,4(1H, 3H)-pyrimidinedione;2,4 (1H, 3H)-Pyrimidinedione, 5-fluoro-;5-Fluoro-2,4(1H,3H)-pyrimidinedione;Fluoroplex;5-Fluoracyl;Efudex;Effluderm (free base);U 8953;Adrucil;Efurix;5-Ftouracyl;2,4(1H,3H)-pyrimidinedione, 5-fluoro-;5-Fluoropyrimidine-2,4-dione;U-8953;Arumel;Kecimeton;Fluoroblastin;2,4-Dioxo-5-fluoropryimidine;Fluro Uracil;Uracil, 5-fluoro- (VAN 8CI);Fluracil;Efudix;Ro 2-9757;5-fluoro-1H-pyrimidine-2,4-dione;5-FU (TN);Carzonal;Fluracilum;5-FU;5FU;5-Fluoro-2,4-pyrimidinedione;Fluril;FU;Fluri;Fluorouracil (JP14/USP);Adrucil (TN);Queroplex;Timazin;Fludrocortisone;5-FLUORACIL (GERMAN);5-FLUORO-2,4(1H,3H)-PYRIMIDINEDI-ONE;5-FLUORPROPYRIMIDINE-2,4-DIONE;5-FLUORO-2,4-PYRIMI-DINEDIONE;5-FLUORURACIL (GERMAN);NSC-19893;5-Fluoro Uracil;5-Fluoropyrimidine;Carmofur 5-Fluoro Uracil;5-Fluorouracl;5-Fluorouracilum;

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Identification
NameFluorouracil (5-Fluorouracil)
CAS51-21-8
SynonymsRo-2-9757;Phtoruracil;Ulup;2,4(1H,3H)-Pyrimidinedione,5-fluoro-;Phthoruracil;Uracil, 5-fluoro-;5-Fluoro-2,4(1H, 3H)-pyrimidinedione;2,4 (1H, 3H)-Pyrimidinedione, 5-fluoro-;5-Fluoro-2,4(1H,3H)-pyrimidinedione;Fluoroplex;5-Fluoracyl;Efudex;Effluderm (free base);U 8953;Adrucil;Efurix;5-Ftouracyl;2,4(1H,3H)-pyrimidinedione, 5-fluoro-;5-Fluoropyrimidine-2,4-dione;U-8953;Arumel;Kecimeton;Fluoroblastin;2,4-Dioxo-5-fluoropryimidine;Fluro Uracil;Uracil, 5-fluoro- (VAN 8CI);Fluracil;Efudix;Ro 2-9757;5-fluoro-1H-pyrimidine-2,4-dione;5-FU (TN);Carzonal;Fluracilum;5-FU;5FU;5-Fluoro-2,4-pyrimidinedione;Fluril;FU;Fluri;Fluorouracil (JP14/USP);Adrucil (TN);Queroplex;Timazin;Fludrocortisone;5-FLUORACIL (GERMAN);5-FLUORO-2,4(1H,3H)-PYRIMIDINEDI-ONE;5-FLUORPROPYRIMIDINE-2,4-DIONE;5-FLUORO-2,4-PYRIMI-DINEDIONE;5-FLUORURACIL (GERMAN);NSC-19893;5-Fluoro Uracil;5-Fluoropyrimidine;Carmofur 5-Fluoro Uracil;5-Fluorouracl;5-Fluorouracilum;
EINECS(EC#)200-085-6
Molecular FormulaC4H3FN2O2
Molecular Weight130.0772
Chemical Properties
Appearancewhite to nearly white crystalline powder
refractive index1.542
storage tempStore at 0-5
Sensitive Air Sensitive
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard Xn:Harmful
Risk R20/21/22
Safety

Hazard Codes:?Xn,Xi ;T;C
Risk Statements: 20/21/22?
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36/37/39-22?
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.?
S22: Do not breathe dust.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: YR0350000
F: 10-23
Hazard Note: Irritant/Highly Toxic
TSCA: T
HazardClass: 6.1
PackingGroup: III
HS Code: 29335995


HS Code 29335995

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 30mg/kg (30mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 303, 1978.
guinea pig LD50 intravenous 25mg/kg (25mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Japanese Journal of Pharmacology. Vol. 30, Pg. 871, 1980.
hamster LD10 parenteral 140mg/kg (140mg/kg) ? Journal of Surgical Oncology. Vol. 15, Pg. 355, 1980.
human TDLo intravenous 6mg/kg/3D (6mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 British Medical Journal. Vol. 1, Pg. 547, 1978.
human TDLo oral 450mg/kg/30D (450mg/kg) GASTROINTESTINAL: OTHER CHANGES

BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE		 Cancer Vol. 39, Pg. 1936, 1977.
man TDLo intravenous 39mg/kg/1D-I (39mg/kg) CARDIAC: CHANGES IN CORONARY ARTERIES American Heart Journal. Vol. 114, Pg. 433, 1987.
man TDLo intravenous 122mg/kg/9W-I (122mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Australian and New Zealand Journal of Medicine. Vol. 22, Pg. 385, 1992.
mouse LD50 intracrebral 41600ug/kg (41.6mg/kg) PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE		 Chemotherapy Vol. 15, Pg. 519, 1967.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg) ? Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 7, Pg. 100, 1977.
mouse LD50 intravenous 81mg/kg (81mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
mouse LD50 oral 115mg/kg (115mg/kg) ? Journal of Medicinal Chemistry. Vol. 21, Pg. 738, 1978.
mouse LD50 subcutaneous 169mg/kg (169mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
mouse LD50 unreported 171mg/kg (171mg/kg) ? Cancer Research. Vol. 46, Pg. 2703, 1986.
mouse LDLo intratracheal 200mg/kg (200mg/kg) ? Toxicology Letters. Vol. 30, Pg. 63, 1986.
rabbit LD50 oral 18900ug/kg (18.9mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Kiso to Rinsho. Clinical Report. Vol. 8, Pg. 2603, 1974.
rabbit LDLo intravenous 15mg/kg (15mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION Japanese Journal of Pharmacology. Vol. 30, Pg. 871, 1980.
rat LD50 intramuscular 240mg/kg (240mg/kg) ? K'at'ollik Taehak Uihakpu Nonmunjip. Journal of Catholic Medical College. Vol. 38, Pg. 481, 1985.
rat LD50 intraperitoneal 70mg/kg (70mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 569, 1971.
rat LD50 intravenous 245mg/kg (245mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: NAUSEA OR VOMITING		 Oyo Yakuri. Pharmacometrics. Vol. 5, Pg. 569, 1971.
rat LD50 oral 230mg/kg (230mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
rat LD50 parenteral 500mg/kg (500mg/kg) ? Recent Results in Cancer Research. Vol. 52, Pg. 76, 1975.
rat LD50 rectal 884mg/kg (884mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: OTHER CHANGES		 Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1309, 1978.
rat LD50 subcutaneous 217mg/kg (217mg/kg) ? Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 4, Pg. 90, 1973.
women TDLo intravenous 27mg/kg/4D-C (27mg/kg) CARDIAC: OTHER CHANGES British Medical Journal. Vol. 294, Pg. 125, 1987.
women TDLo intravenous 150mg/kg/17W- (150mg/kg) BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA British Journal of Haematology. Vol. 65, Pg. 357, 1987.

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