51-45-6|2-imidazol-4-ylethylamineProducts Supply - Chemical intermediates Network

2-imidazol-4-ylethylamine cas no:51-45-6

Synonyms: Histamine Base; histamine free base crystalline; Histamine, Free Base; Histamine; L-Histamin base; 1H-Imidazole-4-ethanamine; 2-(4-Imidazolyl)ethylamine; 4-(2-Aminoethyl)-1H-imidazole

Identification

Name2-imidazol-4-ylethylamine
CAS51-45-6
SynonymsHistamine Base; histamine free base crystalline; Histamine, Free Base; Histamine; L-Histamin base; 1H-Imidazole-4-ethanamine; 2-(4-Imidazolyl)ethylamine; 4-(2-Aminoethyl)-1H-imidazole
EINECS(EC#)200-100-6
Molecular FormulaC5H9N3
Molecular Weight111.15

Chemical Properties

AppearanceYellow crystals.
refractive index1.562
storage temp−20°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard Xn:Harmful;
Risk R22;R36/37/38;R42/43
Safety

Hazard Codes of Histamine (CAS NO.51-45-6): Xn
Risk Statements: 22-36/37/38-42/43
R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.
R42/43: May cause sensitization by inhalation and skin contact.
Safety Statements: 22-26-36/37
S22: Do not breathe dust.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: MS1050000
F: 3-10-23
HazardClass: 6.1(b)
PackingGroup: III

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	subcutaneous	34mg/kg (34mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.
dog	LD50	intravenous	7mg/kg (7mg/kg)	CARDIAC: OTHER CHANGES	Indian Veterinary Journal. Vol. 57, Pg. 31, 1980.
dog	LDLo	subcutaneous	28500ug/kg (28.5mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
frog	LDLo	subcutaneous	1700mg/kg (1700mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
guinea pig	LD50	intraperitoneal	5mg/kg (5mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 736, 1948.
guinea pig	LD50	intravenous	180ug/kg (0.18mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 95, Pg. 45, 1949.
guinea pig	LDLo	oral	200mg/kg (200mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
guinea pig	LDLo	subcutaneous	8mg/kg (8mg/kg)		Farmaco, Edizione Scientifica. Vol. 9, Pg. 379, 1954.
monkey	LDLo	intravenous	50mg/kg (50mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
mouse	LD50	intraperitoneal	725mg/kg (725mg/kg)		British Journal of Pharmacology and Chemotherapy. Vol. 17, Pg. 137, 1961.
mouse	LD50	intravenous	385mg/kg (385mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
mouse	LD50	oral	220mg/kg (220mg/kg)		Japanese Journal of Toxicology. Vol. 4, Pg. 105, 1991.
mouse	LD50	subcutaneous	2500mg/kg (2500mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ATAXIA	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
rabbit	LDLo	intravenous	2mg/kg (2mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 784, 1948.
rabbit	LDLo	subcutaneous	12mg/kg (12mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 718, 1948.
rat	LD50	intravenous	630mg/kg (630mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 89, 1979.
rat	LDLo	subcutaneous	250mg/kg (250mg/kg)	AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 461, 1937.

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2-imidazol-4-ylethylamine cas no:51-45-6

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