51-55-8|Benzeneacetic acid, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl esterProducts Supply

Benzeneacetic acid, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester cas no:51-55-8

Synonyms: 1aH,5aH-Tropan-3a-ol (?à)-tropate (ester) (8CI);Benzeneacetic acid, a-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-;Atropin;Tropine tropate;dl-Hyoscyamine;

Identification

NameBenzeneacetic acid, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
CAS51-55-8
Synonyms1aH,5aH-Tropan-3a-ol (?à)-tropate (ester) (8CI);Benzeneacetic acid, a-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-;Atropin;Tropine tropate;dl-Hyoscyamine;
EINECS(EC#)200-104-8
Molecular FormulaC₁₇H₂₃NO₃
Molecular Weight289.41

Chemical Properties

Appearancepowder
refractive index1.581

Safety Data

Hazard T+: Very toxic;
Risk R26/28
Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion and intramuscular routes: visual field changes, mydriasis (pupillary dilation), and muscle weakness. An experimental teratogen. Other experimental reproductive effects. An alkaloid. When heated to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Very T+ Harmful Xn
Risk Statements: 26/28-36/37/38-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R26/28:Very toxic by inhalation and if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 25-45-36-26
S25:Avoid contact with eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

HS Code 29399900

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	70mg/kg (70mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 483, 1948.
cat	LDLo	subcutaneous	130mg/kg (130mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 1, 1937.
dog	LDLo	intravenous	50mg/kg (50mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: NAUSEA OR VOMITING	Proceedings of the Society for Experimental Biology and Medicine. Vol. 40, Pg. 244, 1939.
dog	LDLo	unreported	60mg/kg (60mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 513, 1948.
frog	LDLo	intramuscular	750mg/kg (750mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Proceedings of the Society for Experimental Biology and Medicine. Vol. 40, Pg. 244, 1939.
frog	LDLo	subcutaneous	1gm/kg (1000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1311, 1935.
guinea pig	LD50	intraperitoneal	400mg/kg (400mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952.
guinea pig	LD50	oral	1100mg/kg (1100mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952.
human	TDLo	intramuscular	1ug/kg (0.001mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE	"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982.
human	TDLo	oral	33ug/kg (0.033mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE BEHAVIORAL: MUSCLE WEAKNESS	Journal of Toxicology, Clinical Toxicology. Vol. 22, Pg. 581, 1984/1985.
man	LDLo	unreported	143ug/kg (0.143mg/kg)		"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 482, 1948.
man	TDLo	intramuscular	175ug/kg (0.175mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"	Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 32, Pg. 250, 1973.
man	TDLo	intravenous	14ug/kg (0.014mg/kg)	BEHAVIORAL: HEADACHE VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Annals of Internal Medicine. Vol. 101, Pg. 720, 1984.
mouse	LD50	intradermal	550mg/kg (550mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 59, Pg. 149, 1938.
mouse	LD50	intraperitoneal	30mg/kg (30mg/kg)		Journal of Medicinal Chemistry. Vol. 31, Pg. 683, 1988.
mouse	LD50	intravenous	30mg/kg (30mg/kg)		Journal of Medicinal Chemistry. Vol. 28, Pg. 1760, 1985.
mouse	LD50	oral	75mg/kg (75mg/kg)	BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 59, Pg. 149, 1938.
mouse	LD50	subcutaneous	428mg/kg (428mg/kg)		Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 11, Pg. 457, 1980.
rabbit	LD50	intradermal	500mg/kg (500mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 59, Pg. 149, 1938.
rabbit	LD50	intravenous	50mg/kg (50mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 59, Pg. 149, 1938.
rabbit	LD50	oral	600mg/kg (600mg/kg)	BEHAVIORAL: EXCITEMENT BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 59, Pg. 149, 1938.
rabbit	LDLo	intraperitoneal	350ug/kg (0.35mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION CARDIAC: PULSE RATE	Journal of Pharmacology and Experimental Therapeutics. Vol. 60, Pg. 14, 1937.
rabbit	LDLo	subcutaneous	500mg/kg (500mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1311, 1935.
rat	LD50	intramuscular	920mg/kg (920mg/kg)		Drug and Chemical Toxicology. Vol. 1, Pg. 355, 1978.
rat	LD50	intraperitoneal	280mg/kg (280mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 105, Pg. 166, 1952.
rat	LD50	intravenous	73mg/kg (73mg/kg)		Schweizerische Medizinische Wochenschrift. Vol. 76, Pg. 1282, 1946.
rat	LD50	oral	500mg/kg (500mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 393, 1965.
rat	LD50	subcutaneous	250mg/kg (250mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 68, Pg. 339, 1942.

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Manus Aktteva: Tel:+91-(79)-65123395; Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006,

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China Langchem Inc.: Tel:+86-(21)-58956006; Address: 514 Room, 1# Building, 88# Cailun Road, Zhangjiang High Tech Park, Shanghai 201203,

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Chemrio International Limited: Tel:+86-(574)-2789-1268, +86-13957895864; Address: Room 611-612 Wante Business Center, No.487 Yangmuqi Road, Hi-tech Park, Ningbo, Zhejiang 315040,

AOKChem Co., Ltd.: Tel:+86-(21)-50791030 / 68712331; Address: Room 203, Block D, No.333 Cailun Road, Zhangjiang High-tech Park, Shanghai 201203,

Chemner Pharma: Tel:+86-(23)-62482345; Address: 668# International Exhibtion and Conference Center, Chongqing, Sichuan 400060,

Shanghai Inno-trans Chemical Co., Ltd: Tel:0086-21-64825013; Address: Rm 501, Building 10, Zhenping Rd. 176, Shanghai 200062,

Benzeneacetic acid, alpha-(hydroxymethyl)-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester cas no:51-55-8

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