Neostigmine methyl sulfate cas no:51-60-5

NameNeostigmine methyl sulfate
CAS51-60-5
SynonymsProstigmin methyl sulfate;Hodostin;Neostigmeth;Benzenaminium,3-[[(dimethylamino)carbonyl]- oxy]-N,N,N-trimethyl-,methyl sulfate;AR-32;Normastigmin;Carbamic acid, N,N-dimethyl-, 3-(trimethylammonio)phenyl ester, methyl sulfate;Ammonium, (m-hydroxyphenyl)trimethyl-, methyl sulfate, dimethylcarbamate;Juvastigmin;Polstigmine;Stigmanol methyl sulfate;(3-Hydroxyphenyl)trimethylammonium methyl sulfate dimethylcarbamic ester;[3-(Dimethylcarbamoyl)oxyphenyl]trimethylammonium methyl sulfate;Syntostigmin methyl sulfate;Synthostigmine methyl sulfate;[3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium; sulfonatooxymethane;Vagostigmin;Philostigmin methyl sulfate;Kirkstigmine methyl sulfate;(m-Hydroxyphenyl)trimethylammonium methyl sulfate dimethylcarbamate;Benzenaminium, 3-[[ (dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, methyl sulfate;[3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium; sulfooxymethane;Syntostigmin;Syntostigmine methyl sulfate;Dimethylcarbamic ester of 3-oxyphenyltrimethylammonium methylsulfato;Leostigmine methyl sulfate;Synstigmine;Proserine methyl sulfate;Proserine;Neostigmine monomethyl sulfate;Carbamic acid, dimethyl-, ester with (m-hydroxyphenyl)trimethylammonium methyl sulfate;[3-(Dimethylcarbamoxy)phenyl]trimethylammonium methyl sulfate;Neostigmine methosulfate;Vagostigmine methyl sulfate;[3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium;Syntostigmin (injection);Prostigmin;SB-23;Neoeserine methyl sulfate;Prostigmine methyl sulfate;Kirkstigmine;Proserin;Ammonium, [3-(dimethylcarbamoyloxy)phenyl]trimethyl-, methyl sulfate;Stigmosan methyl sulfate;Eustigmin methyl sulfate;Neostigmine methylsulfates;TL-1394;Neostigmine methylsulfate (JP14/USP);Prostigmin (TN);Neostigmine Methylsulfate USP29/EP5;Nefazodone;neostigmine metilsulfate;
EINECS(EC#)200-109-5
Molecular FormulaC₁₃H₂₂N₂O₆S
Molecular Weight334.43

AppearanceCrystalline Solid
storage temp−20°C

Hazardclass6.1(a)

Hazard T+: Very toxic;
Risk R26/27/28;R36/37/38;R42/43
Safety

A deadly poison by ingestion, intravenous, subcutaneous, intraperitoneal, and intramuscular routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of SO_x, NH₃, and NO_x. See also Carbamates.
Hazard Codes: T+
Risk Statements: 28-36/37/38-42/43-26/27/28
R36/37/38:Irritating to eyes, respiratory system and skin ;
R42/43:May cause sensitization by inhalation and skin contact ;
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed ;
Safety Statements: 36-45-36/37/39-28
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) ;
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection ;
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer);
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: CY1225000
HazardClass: 6.1(a)
PackingGroup: II

1.		scu-rat LD50:334 µg/kg		TXAPA9    Toxicology and Applied Pharmacology. 25 (1973),569.
2.		orl-mus LD50:7500 µg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 99 (1950),16.
3.		ipr-mus LD50:230 µg/kg		ATXKA8    Archiv fuer Toxikologie. 29 (1972),39.
4.		scu-mus LD50:420 µg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 99 (1950),16.
5.		ivn-mus LD50:160 µg/kg		JPETAB    Journal of Pharmacology and Experimental Therapeutics. 99 (1950),16.
6.		scu-dog LD50:50 µg/kg		NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB158-508 .
7.		scu-cat LDLo:50 µg/kg		NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB158-508 .
8.		ims-rbt LD50:310 µg/kg		AIPTAK    Archives Internationales de Pharmacodynamie et de Therapie. 81 (1950),276.