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Histamine phosphate cas no:51-74-1

Synonyms: Histamine acid phosphate;1H-Imidazole-4-ethanamine,compounds,phosphate (1:2);Histamine Diphosphate;Histamine bisphosphate monohydrate;

Identification
NameHistamine phosphate
CAS51-74-1
SynonymsHistamine acid phosphate;1H-Imidazole-4-ethanamine,compounds,phosphate (1:2);Histamine Diphosphate;Histamine bisphosphate monohydrate;
EINECS(EC#)200-118-4
Molecular FormulaC5H9N3.2(H3PO4)
Molecular Weight307.13
Chemical Properties
AppearanceWhite crystal powder
storage temp−20°C
Safety Data

Hazard Xn:;
Risk 20/21/22-36/37/38-42/43-41-37/38-22
Safety

A deadly poison by intravenous and parenteral routes. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of NOx and POx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 608ug/kg (0.608mg/kg) LUNGS, THORAX, OR RESPIRATION: BRONCHIOLAR CONSTRICTION Journal of Pharmaceutical Sciences. Vol. 57, Pg. 1543, 1968.
guinea pig LDLo parenteral 746ug/kg (0.746mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1574, 1970.
mouse LD50 intraperitoneal 913mg/kg (913mg/kg)   Journal of Pharmaceutical Sciences. Vol. 59, Pg. 1659, 1970.
mouse LD50 intravenous 333mg/kg (333mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 90, Pg. 726, 1955.
mouse LD50 oral 807mg/kg (807mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 122, Pg. 685, 1966.
rabbit LD50 intravenous 2763ug/kg (2.763mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 75, Pg. 299, 1942.
rabbit LDLo parenteral 1mg/kg (1mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925.
rat LD50 intraperitoneal 1781mg/kg (1781mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 444, 1957.
rat LDLo intravenous 900mg/kg (900mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA Journal of Pharmacology and Experimental Therapeutics. Vol. 24, Pg. 101, 1925.

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