51-79-6|UrethaneProducts Supply - Chemical intermediates Network

Urethane cas no:51-79-6

Synonyms: Urethane (Ethyl Carbamate); Ethyl carbamate; Carbamicacidethylester,98%; Poly(carbonate urethane); Ethyluretan

Identification

NameUrethane
CAS51-79-6
SynonymsUrethane (Ethyl Carbamate); Ethyl carbamate; Carbamicacidethylester,98%; Poly(carbonate urethane); Ethyluretan
EINECS(EC#)200-123-1
Molecular FormulaC3H7NO2
Molecular Weight89.09

Chemical Properties

Appearancewhite crystalline powder
refractive index1.4144 (51 C)
storage tempKeep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Safety Data

Hazard T:Toxic
Risk R45
Safety

Hazard Codes of Urethane (CAS NO.51-79-6): T
Risk Statements: 45
R45: May cause cancer.
Safety Statements: 53-45-9
S53: Avoid exposure - obtain special instructions before use.
S45:I n case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S9: Keep container in a well-ventilated place.
WGK Germany: 3
RTECS: FA8400000
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. A transplacental carcinogen. Moderately toxic by ingestion, intraperitoneal, subcutaneous, intramuscular, parenteral, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Causes depression of bone marrow and occasionally focal degeneration in the brain. Can also produce central nervous system depression, nausea and vomiting. Has been found in over 1000 beverages sold in the United States. The most heavily contaminated liquors are bourbons, sherries, and fruit brandies (some had 1000 to 12,000 ppb urethane). Many whiskeys, table and dessert wines, brandies, and liqueurs contain potentially hazardous amounts of urethane. The allowable limit for urethane in alcoholic beverages is 125 ppb. It is formed as a side product during processing.

Hot aqueous acids or alkalies decompose urethane to ethanol, carbon dioxide, and ammonia. Reacts with phosphorus pentachloride to form an explosive product. When heated it emits toxic fumes of NO_x. Used as an intermediate in the manufacture of pharmaceuticals, pesticides, and fungicides. See also CARBAMATES.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
chicken	LDLo	oral	2188mg/kg (2188mg/kg)		"Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
guinea pig	LDLo	intraarterial	800mg/kg (800mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig	LDLo	intravenous	800mg/kg (800mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
mouse	LD50	intraperitoneal	1539mg/kg (1539mg/kg)		Progress in Mutation Research. Vol. 1, Pg. 682, 1981.
mouse	LD50	intravenous	500mg/kg (500mg/kg)		Acta Pharmaceutica Jugoslavica. Vol. 5, Pg. 43, 1955.
mouse	LD50	oral	2500mg/kg (2500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 595, 1959.
mouse	LD50	subcutaneous	1750mg/kg (1750mg/kg)		Gann. Japanese Journal of Cancer Research. Vol. 63, Pg. 731, 1972.
mouse	LD50	unreported	2gm/kg (2000mg/kg)		British Journal of Cancer. Vol. 6, Pg. 160, 1952.
mouse	LDLo	parenteral	1gm/kg (1000mg/kg)	GASTROINTESTINAL: PERITONITIS	Progress Report for Contract No. PH-43-63-1132, Submitted to the National Cancer Institute by Scientific Associates, Inc. Vol. PH-43-62-483,
pigeon	LDLo	oral	800mg/kg (800mg/kg)		"Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit	LDLo	intravenous	2gm/kg (2000mg/kg)		"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 272, 1973.
rat	LD50	intramuscular	1400mg/kg (1400mg/kg)		Zeitschrift fuer Krebsforschung und Klinische Onkologie. Vol. 84, Pg. 227, 1975.
rat	LD50	intraperitoneal	1500mg/kg (1500mg/kg)		Cancer Research. Vol. 26, Pg. 1448, 1966.
rat	LD50	oral	1809mg/kg (1809mg/kg)		Cancer Letters Vol. 57, Pg. 37, 1991.
rat	LDLo	subcutaneous	1800mg/kg (1800mg/kg)		Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 182, Pg. 348, 1936.

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Urethane cas no:51-79-6

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