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Urethane cas no:51-79-6

Synonyms: Urethane (Ethyl Carbamate); Ethyl carbamate; Carbamicacidethylester,98%; Poly(carbonate urethane); Ethyluretan

Identification
NameUrethane
CAS51-79-6
SynonymsUrethane (Ethyl Carbamate); Ethyl carbamate; Carbamicacidethylester,98%; Poly(carbonate urethane); Ethyluretan
EINECS(EC#)200-123-1
Molecular FormulaC3H7NO2
Molecular Weight89.09
Chemical Properties
Appearancewhite crystalline powder
refractive index1.4144 (51 C)
storage tempKeep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Safety Data

Hazard T:Toxic
Risk R45
Safety

Hazard Codes of Urethane (CAS NO.51-79-6): T
Risk Statements: 45 
R45: May cause cancer.
Safety Statements: 53-45-9 
S53: Avoid exposure - obtain special instructions before use. 
S45:I n case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S9: Keep container in a well-ventilated place.
WGK Germany: 3
RTECS: FA8400000
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. A transplacental carcinogen. Moderately toxic by ingestion, intraperitoneal, subcutaneous, intramuscular, parenteral, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. Causes depression of bone marrow and occasionally focal degeneration in the brain. Can also produce central nervous system depression, nausea and vomiting. Has been found in over 1000 beverages sold in the United States. The most heavily contaminated liquors are bourbons, sherries, and fruit brandies (some had 1000 to 12,000 ppb urethane). Many whiskeys, table and dessert wines, brandies, and liqueurs contain potentially hazardous amounts of urethane. The allowable limit for urethane in alcoholic beverages is 125 ppb. It is formed as a side product during processing.

 

Hot aqueous acids or alkalies decompose urethane to ethanol, carbon dioxide, and ammonia. Reacts with phosphorus pentachloride to form an explosive product. When heated it emits toxic fumes of NOx. Used as an intermediate in the manufacture of pharmaceuticals, pesticides, and fungicides. See also CARBAMATES.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo oral 2188mg/kg (2188mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
guinea pig LDLo intraarterial 800mg/kg (800mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
guinea pig LDLo intravenous 800mg/kg (800mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
mouse LD50 intraperitoneal 1539mg/kg (1539mg/kg)   Progress in Mutation Research. Vol. 1, Pg. 682, 1981.
mouse LD50 intravenous 500mg/kg (500mg/kg)   Acta Pharmaceutica Jugoslavica. Vol. 5, Pg. 43, 1955.
mouse LD50 oral 2500mg/kg (2500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 595, 1959.
mouse LD50 subcutaneous 1750mg/kg (1750mg/kg)   Gann. Japanese Journal of Cancer Research. Vol. 63, Pg. 731, 1972.
mouse LD50 unreported 2gm/kg (2000mg/kg)   British Journal of Cancer. Vol. 6, Pg. 160, 1952.
mouse LDLo parenteral 1gm/kg (1000mg/kg) GASTROINTESTINAL: PERITONITIS Progress Report for Contract No. PH-43-63-1132, Submitted to the National Cancer Institute by Scientific Associates, Inc. Vol. PH-43-62-483,
pigeon LDLo oral 800mg/kg (800mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LDLo intravenous 2gm/kg (2000mg/kg)   "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 272, 1973.
rat LD50 intramuscular 1400mg/kg (1400mg/kg)   Zeitschrift fuer Krebsforschung und Klinische Onkologie. Vol. 84, Pg. 227, 1975.
rat LD50 intraperitoneal 1500mg/kg (1500mg/kg)   Cancer Research. Vol. 26, Pg. 1448, 1966.
rat LD50 oral 1809mg/kg (1809mg/kg)   Cancer Letters Vol. 57, Pg. 37, 1991.
rat LDLo subcutaneous 1800mg/kg (1800mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 182, Pg. 348, 1936.

supplier list

Shanghai Yuanji Chemical Co.Ltd.
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Chengdu Wenshi Chemicals Products Co., Ltd.
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Cridel Thermoset Resins Incorporated
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Advance Research Chemicals Inc.
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Sealant Equipment & Engineering
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AKOR Corp.
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Inter Polymer Corporation
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Goly Chemical Co., Ltd.
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Nanjing Samwon International Limited
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Xilin Chemical Group Co., Ltd
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Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071,
Esstech Inc.
Tel:+1-(610)-521-3800, 800-245-3800
Address: PO Box 39 / 48 Powhattan Ave, Essington, Pennsylvania 19029-0039,
Harlan China
Tel:+86-512-69363203
Address: Biobay, SIP China

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