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19-Norpregn-4-en-20-yn-3-one,17-(acetyloxy)-, (17a)- cas no:51-98-9

Synonyms: 19-Nor-17a-pregn-4-en-20-yn-3-one,17-hydroxy-, acetate (6CI,8CI);17-Acetoxy-19-nor-17a-pregn-4-en-20-yn-3-one;17a-Ethinyl-19-nortestosteroneacetate;17a-Ethinyl-4-estrene-17b-ol-acetate-3-one;17b-Acetoxy-17a-ethinyl-4-estren-3-one;17b-Hydroxy-19-nor-17a-pregn-4-en-20-yn-3-one acetate;19-Norethynyltestosterone acetate;Aygestin;Estalis;Gynovlane;Milli-Anovlar;Milligynon;Miniphase;NSC 22844;Norethindrone 17-acetate;Norethindrone acetate;Norethynyltestosteroneacetate;Norlutate;Norlutin acetate;Orlutate;Primolut-Nor;

Identification
Name19-Norpregn-4-en-20-yn-3-one,17-(acetyloxy)-, (17a)-
CAS51-98-9
Synonyms19-Nor-17a-pregn-4-en-20-yn-3-one,17-hydroxy-, acetate (6CI,8CI);17-Acetoxy-19-nor-17a-pregn-4-en-20-yn-3-one;17a-Ethinyl-19-nortestosteroneacetate;17a-Ethinyl-4-estrene-17b-ol-acetate-3-one;17b-Acetoxy-17a-ethinyl-4-estren-3-one;17b-Hydroxy-19-nor-17a-pregn-4-en-20-yn-3-one acetate;19-Norethynyltestosterone acetate;Aygestin;Estalis;Gynovlane;Milli-Anovlar;Milligynon;Miniphase;NSC 22844;Norethindrone 17-acetate;Norethindrone acetate;Norethynyltestosteroneacetate;Norlutate;Norlutin acetate;Orlutate;Primolut-Nor;
EINECS(EC#)200-132-0
Molecular FormulaC22H28O3
Molecular Weight340.46
Chemical Properties
refractive index-34 ° (C=1, Dioxane)
Safety Data

Hazard Xn:Harmful
Risk R40;R48
Safety

Suspected carcinogen with experimental tumorigenic data. Human reproductive effects by ingestion and implant routes: menstrual cycle changes, postpartum effects, and changes in fertility. A human teratogen by an unspecified route with developmental abnormalities of the urogenital system. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in the treatment of menstrual disorders and uterine bleeding.
Safety Information about [(8R,9S,10R,13S,14S,17R)-17-Ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate (51-98-9):
Hazard Codes:?
Xn:?
Risk Statements bout [(8R,9S,10R,13S,14S,17R)-17-Ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate (51-98-9):?
R40: ited evidence of a carcinogenic effect.
R48: Danger of serious damage to health by prolonged exposure.
Safety Statements bout [(8R,9S,10R,13S,14S,17R)-17-Ethynyl-13-methyl-3-oxo-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate (51-98-9):?
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS: RC8965000


Toxicity
1. ???

dlt-mus-orl 1120?mg/kg/4W

??? MUREAV ?? Mutation Research. 26 (1974),535.
2. ???

spm-mus-orl 1120?mg/kg/4W

??? MUREAV ?? Mutation Research. 26 (1974),535.
3. ???

orl-wmn TDLo:2190?μg/kg (52W pre):REP

??? BMJOAE ?? British Medical Journal. 2 (1969),730.
4. ???

unr-wmn TDLo:15?mg/kg (female 13-30W post):TER

??? OBGNAS ?? Obstetrics and Gynecology. 22 (1963),210.

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