|
dog
|
LD50
|
oral
|
240mg/kg (240mg/kg)
|
sense organs and special senses: mydriasis (pupillary dilation): eye
sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
|
mouse
|
LD50
|
intraperitoneal
|
336mg/kg (336mg/kg)
|
behavioral: altered sleep time (including change in righting reflex)
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
|
mouse
|
LD50
|
intravenous
|
189mg/kg (189mg/kg)
|
behavioral: altered sleep time (including change in righting reflex)
behavioral: convulsions or effect on seizure threshold
behavioral: somnolence (general depressed activity)
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
|
mouse
|
LD50
|
oral
|
1340mg/kg (1340mg/kg)
|
behavioral: altered sleep time (including change in righting reflex)
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
|
mouse
|
LD50
|
subcutaneous
|
755mg/kg (755mg/kg)
|
behavioral: altered sleep time (including change in righting reflex)
behavioral: convulsions or effect on seizure threshold
ehavioral: somnolence (general depressed activity)
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
|
rat
|
LD50
|
intraperitoneal
|
421mg/kg (421mg/kg)
|
sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
|
rat
|
LD50
|
intravenous
|
254mg/kg (254mg/kg)
|
sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
|
rat
|
LD50
|
oral
|
4840mg/kg (4840mg/kg)
|
sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
|
rat
|
LD50
|
subcutaneous
|
1130mg/kg (1130mg/kg)
|
sense organs and special senses: ptosis: eye
behavioral: somnolence (general depressed activity)
behavioral: convulsions or effect on seizure threshold
|
Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 1933, 1985.
|
