Ergotaman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'a,10a)- cas no:511-12-6
Synonyms: Ergotamine,9,10-dihydro- (8CI); 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine,ergotaman-3',6',18-trione deriv.; Indolo[4,3-fg]quinoline,ergotaman-3',6',18-trione deriv.; 9,10-Dihydroergotamine; DHE;Dihydroergotamine
NameErgotaman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'a,10a)-
CAS511-12-6
SynonymsErgotamine,9,10-dihydro- (8CI); 8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine,ergotaman-3',6',18-trione deriv.; Indolo[4,3-fg]quinoline,ergotaman-3',6',18-trione deriv.; 9,10-Dihydroergotamine; DHE;Dihydroergotamine
EINECS(EC#)208-123-3
Molecular FormulaC33H37 N5 O5
Molecular Weight583.65
refractive index1.727
Safety
Poison by intravenous and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| cat |
LD50 |
subcutaneous |
68mg/kg (68mg/kg) |
|
Schweizerische Medizinische Wochenschrift. Vol. 76, Pg. 1254, 1946. |
| mouse |
LD50 |
intravenous |
118mg/kg (118mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 105, Pg. 317, 1956. |
| mouse |
LD50 |
oral |
> 8gm/kg (8000mg/kg) |
|
French Medicament Patent Document. Vol. #2292M, |
| mouse |
LD50 |
subcutaneous |
80mg/kg (80mg/kg) |
|
Russian Pharmacology and Toxicology Vol. 31, Pg. 53, 1968. |
| rabbit |
LD50 |
intravenous |
25mg/kg (25mg/kg) |
|
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 105, Pg. 317, 1956. |
| rabbit |
LD50 |
oral |
> 8gm/kg (8000mg/kg) |
|
French Medicament Patent Document. Vol. #2292M, |
