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Quinomycin A (7CI,9CI) cas no:512-64-1

Synonyms: Echinomycin(8CI);9,22-Dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane,cyclic peptide deriv.;Antibiotic A 654I;NSC 13502;NSC 526417;SK 302B;Stereoisomer ofN,N'-[2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane-7,20-diyl]bis[2-quinoxalinecarboxamide];

Identification
NameQuinomycin A (7CI,9CI)
CAS512-64-1
SynonymsEchinomycin(8CI);9,22-Dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane,cyclic peptide deriv.;Antibiotic A 654I;NSC 13502;NSC 526417;SK 302B;Stereoisomer ofN,N'-[2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane-7,20-diyl]bis[2-quinoxalinecarboxamide];
EINECS(EC#)201-958-4
Molecular FormulaC51H64 N12 O12 S2
Molecular Weight1101.39
Chemical Properties
refractive index1.536
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T: Toxic;
Risk R46
Safety

A deadly poison by intraperitoneal, intravenous, and subcutaneous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Hazard Codes: ToxicT
Risk Statements: 46-23/24/25 
R46: May cause heritable genetic damage 
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
Safety Statements: 53-36/37/39-45
S53: Avoid exposure - obtain special instructions before use 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible)
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: JW5250000
F: 10
HazardClass: 6.1(b)
PackingGroup: III


Toxicity
1.    

pic-esc 600 ng/plate

    CNREA8    Cancer Research. 43 (1983),2819.
2.    

dnd-mam:lym 400 nmol/L

    NATUAS    Nature. 252 (1974),653.
3.    

dni-mam:lym 27 µmol/L

    HXPHAU    Handbuch der Experimentellen Pharmakologie. 38 (Pt 2),(1975),623.
4.    

ipr-mus LD50:280 µg/kg

    JANTAJ    Journal of Antibiotics. 31 (1968),465.
5.    

scu-mus LD50:3800 µg/kg

    85ERAY    Antibiotics: Origin, Nature, and Properties. 1 (1978),311.
6.    

ivn-mus LD50:629 µg/kg

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB83-114298 .
7.    

ivn-dog LDLo:89 µg/kg

    NTIS**    National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) PB82-114298 .

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Boc Sciences
Tel:1-631-5046093
Address: 45-16 Ramsey Road Shirley, NY 11967, USA
Boc Sciences
Tel:1-631-5046093
Address: 45-16 Ramsey Road, Shirley, NY 11967, USA

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